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  • Matthias Kühnle, Michael Egger, +5 authors Armin Buschauer
  • Chemistry, Medicine
  • Journal of medicinal chemistry
  • 2009 (First Publication: 26 February 2009)
  • The efflux pumps ABCB1 (p-gp, MDR1) and ABCG2 (BCRP) are expressed to a high extent by endothelial cells at the blood-brain barrier (BBB) and other barrier tissues and are involved in drug resistanceContinue Reading
  • Till M Reher, Detlef Neumann, Armin Buschauer, Roland Seifert
  • Medicine, Chemistry
  • Biochemical pharmacology
  • 2012 (First Publication: 1 July 2012)
  • Eosinophils play a crucial role in the pathogenesis of allergic diseases. Histamine activates eosinophils via the H(4)-receptor (H(4)R). However, pharmacological analysis of the H(4)R in eosinophilsContinue Reading
  • Martina Hubensack, Christine Müller, +4 authors Armin Buschauer
  • Biology, Medicine
  • Journal of Cancer Research and Clinical Oncology
  • 2007 (First Publication: 1 May 2008)
  • PurposePreviously, we studied the effect of co-administration of paclitaxel with the second generation ABCB1 (p-gp) modulator valspodar on the intracerebral growth of human U118-MG glioblastoma inContinue Reading
  • Roland Seifert, Katharina Wenzel-Seifert, +5 authors Sigurd Elz
  • Medicine, Chemistry
  • Journal of Pharmacology and Experimental…
  • 2003 (First Publication: 1 June 2003)
  • Species isoforms of histamine H2-, H3-, and H4-receptors differ in their pharmacological properties. The study aim was to dissect differences between the human H1R (hH1R) and guinea pig H1R (ghH1R).Continue Reading
  • Patrick Igel, Roland Geyer, Andrea Straßer, Stefan Dove, Roland Seifert, Armin Buschauer
  • Chemistry, Medicine
  • Journal of medicinal chemistry
  • 2009 (First Publication: 22 October 2009)
  • Recently, we identified high-affinity human histamine H3 (hH3R) and H4 receptor (hH4R) ligands among a series of NG-acylated imidazolylpropylguanidines, which were originally designed as histamine H2Continue Reading
  • Roland Seifert, Ariane Höer, I. Schwaner, Armin Buschauer
  • Chemistry, Medicine
  • Molecular pharmacology
  • 1992
  • Histamine H1 receptors mediate activation of phospholipase C, with subsequent increases in cytosolic Ca2+ concentration ([Ca2+]i), and H2 receptors mediate accumulation of cAMP. HL-60 promyelocytesContinue Reading