Armen Zakharyan

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BACKGROUND Recent pharmacodynamic and retrospective clinical analyses have suggested that proton pump inhibitors (PPIs) may modify the antiplatelet effects of clopidogrel bisulfate. METHODS We conducted a retrospective cohort study of persons enrolled in a multistate health insurance plan with commercial and Medicare clients to evaluate adverse clinical(More)
BACKGROUND A national pharmacy benefits management company implemented a rheumatoid arthritis (RA) disease therapy management (DTM) program as an enhanced offering to patients receiving specialty pharmacy services. The program was designed to improve medication adherence, maximize therapeutic outcomes, and enhance physical functioning and health-related(More)
OBJECTIVE To examine medication adherence among Medicare Part D beneficiaries initiating oral anti-diabetic medications and explore whether there is any association of using mail-order pharmacy (vs. retail pharmacy) with better adherence in this patient population. RESEARCH DESIGN AND METHODS Using administrative pharmacy claims data, we conducted a(More)
BACKGROUND Critical limb ischemia (CLI) represents the most severe clinical manifestation of peripheral arterial disease (PAD) and is the major cause of ischemic amputation in the United States. Risk factors and the associated incidence and prevalence of CLI have not been well described in the general population. This study describes the risk factors for(More)
Cigarette smoking in college is often described as social smoking, but the term lacks definition and implicitly discounts dependence. We report on college students' use of the terms social smoker and smoker. Students who currently smoked cigarettes were asked whether they considered themselves smokers, and whether they smoked because they were social(More)
OBJECTIVES To examine the association between atypical antipsychotic medications and incident treatment for diabetes mellitus or hyperlipidemia in elderly adults without diagnoses of schizophrenia or bipolar disorder. DESIGN Two case-control studies using medical and pharmacy claims data. SETTING United States managed care population from multiple(More)
Current guidelines recommend obtaining an ankle-brachial index (ABI) to screen for peripheral artery disease (PAD) in subjects at risk. Previous work demonstrated that a combination of β(2)-microglobulin, cystatin C, high-sensitivity C-reactive protein and glucose was associated with PAD. This study evaluated the ability of these biomarkers combined with(More)
PURPOSE To determine if switching from select branded to generic equivalent antiepileptic drugs (AEDs) in patients with epilepsy is associated with adverse outcomes. METHODS A retrospective cohort study using a large health insurance plan claims database comparing patients with epilepsy who switched from brand to generic equivalent phenytoin, lamotrigine,(More)
Changes in the proliferative status of cells are accompanied by morphological, structural, and functional modifications of cell membranes. The available data on the lipid (phospholipid) composition of dividing and latent cells in vitro are controversial; therefore, the goal of this study was to analyze the spectrum and quantitative composition of individual(More)
Objective. To study free-radical lipid oxidation, oxidative protein modification, and glutathione peroxidase and glutathione reductase activities, as well as the end product of nitric oxide, i.e., nitrite, in the mitochondrial fraction of the brain in animals during experimental cerebral edema and treatment with taurine. Materials and methods. Toxic(More)
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