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c-myc gene was amplified in the human ovarian tumor line OS-4 5-6-fold and in the OvCa-1 line 3-4-fold. The relative amount of the transcript from the c-myc gene to the total RNA in OS-4 was 6-fold that for normal cells.
Mitogen-activated protein kinases (MAPKs) are highly conserved protein kinase modules, and they control fundamental cellular processes. While the activation of MAPKs has been well studied, little is known on the mechanisms driving their inactivation. Here we uncover a role for ubiquitination in the inactivation of a MAPK module.… (More)