Armand W A A van Oosterwijck

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BACKGROUND Central nervous system adverse effects, such as sedation, often accompany the use of first-generation antihistamines. These effects might interfere with memory functioning and psychomotor performance. Levocetirizine was recently introduced as a new antihistamine said to be free from sedative effects. OBJECTIVE We sought to investigate the(More)
RATIONALE Sedation following antihistamine use poses a danger to ambulant patients involved in daily activities such as driving. OBJECTIVE To investigate effects of levocetirizine (5 mg), diphenhydramine (50 mg), and placebo on driving ability during normal traffic. METHODS Forty-eight healthy volunteers participated in a double-blind,(More)
BACKGROUND Reduced metabolic activity in frontal brain regions, and reduced striatal dopamine receptor densities have been shown in alcohol dependent patients. Little is known on functional changes in the fronto-striatal-thalamic dopaminergic neurocircuitry in these patients. The objective of this study was to assess sensitivity of prefrontal dopamine(More)
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