Arman Alimohammadi

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BACKGROUND Splenectomy is a clinical risk factor for complicated thrombosis. We hypothesized that the loss of the mechanical filtering function of the spleen may enrich for thrombogenic phospholipids in the circulation, thereby affecting the vascular remodeling of thrombosis. METHODS AND RESULTS We investigated the effects of splenectomy both in chronic(More)
OBJECTIVE Restoration of patency is a natural target of vascular remodeling after venous thrombosis that involves vascular endothelial cells and smooth muscle cells, as well as leukocytes. Acute pulmonary emboli usually resolve <6 months. However, in some instances, thrombi transform into fibrous vascular obstructions, resulting in occlusion of the deep(More)
BACKGROUND To investigate the clinical utility of pretreatment plasma fibrinogen levels in malignant pleural mesothelioma (MPM) patients. METHODS A retrospective multicenter study was performed in histologically proven MPM patients. All fibrinogen levels were measured at the time of diagnosis and clinical data were retrospectively collected after approval(More)
R estoration of vascular patency is a key target of vascular remodeling after thrombosis. Apart from plasmin-driven fibrinolysis as a major proteolytic system in venous thrombus resolution, angiogenesis 3 and leukocyte recruitment 4 hallmark this process, with the expression of vascular endothe-lial growth factor (VEGF), basic fibroblast growth factor, 5(More)
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