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OBJECTIVE In observational cohorts, adiponectin is inversely associated and free fatty acids (FFAs) are directly associated with incident coronary heart disease (CHD). Adiponectin tends to be reduced… Continue Reading
BACKGROUND Peroxisome proliferator-activated receptors (PPARs) regulate transcription of genes involved in glucose uptake, lipid metabolism, and inflammation. Aleglitazar is a potent dual PPAR… Continue Reading
IMPORTANCE No therapy directed against diabetes has been shown to unequivocally reduce the excess risk of cardiovascular complications. Aleglitazar is a dual agonist of peroxisome… Continue Reading
Objective Insulin resistance has been linked to development and progression of atherosclerosis and is present in most patients with type 2 diabetes. Whether the degree of insulin resistance predicts… Continue Reading
BACKGROUND The AleCardio trial aimed to characterize the efficacy and safety of PPARαγ agonist aleglitazar in patients with type 2 diabetes mellitus and acute coronary syndrome. The trial terminated… Continue Reading
AIMS Methoxy polyethylene glycol-epoetin beta (continuous erythropoietin receptor activator, C.E.R.A.) is used for the treatment of anaemia in adults with chronic kidney disease (CKD). Patients… Continue Reading
In observational cohorts, adiponectin is inversely associated and free fatty acids (FFAs) are directly associated with incident coronary heart disease (CHD). Adiponectin tends to be reduced and FFAs… Continue Reading
Background C.E.R.A. indicated in Chronic Kidney Disease adult patients to correct and maintain hemoglobin (Hb) levels is approved in Europe and US since 2007; pediatric development is ongoing. A… Continue Reading
Introduction: Adiponectin (Adn), a hormone secreted by adipocytes, modulates insulin action and sensitivity, and has putative anti-atherogenic effects. Observational cohort studies show an inverse ...
Background: The homeostasis model assessment of insulin resistance (HOMA-IR) has been linked to cardiovascular (CV) events in non-diabetic patients, but its predictive value in patients with type 2… Continue Reading