Arlene Johnson

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The novel atypical antipsychotic ziprasidone has a pharmacologic profile notable for potent agonism of serotonin (5-HT)1A receptors, antagonism at 5-HT1D receptors, and reuptake inhibition of norepinephrine. 5-HT1A receptor agonism, in particular, suggests anxiolytic activity, and ziprasidone has shown preliminary efficacy in treating the symptoms of(More)
Toluene is a widely used organic solvent causing loss of auditory sensitivity in rats and presumably in humans. Also, the hearing loss in humans occupationally exposed to noise has been reported to be aggravated by simultaneous exposure to solvents. The aim of the present investigation was to study the effects of toluene, alone or in combination with other(More)
Rats were exposed to toluene by inhalation (1400 ppm, 16 h/d, 8 days) and sacrificed for morphological investigations at 3 and 5 days after the start of the exposure, and 4 days and 6 weeks after the end of the exposure. The cochleae were removed and prepared for light microscopy and scanning electron microscopy. After 3 days of toluene exposure no loss of(More)
Rats were exposed to toluene (1000 ppm, 16 h/d, 5 d/w, 2 w), or noise (100 dB Leq, 10 h/d, 7 d/w, 4 w) or toluene followed by noise. Auditory function was tested by brainstem audiometry using a 1/3 octave filtered sine wave stimulus at the frequencies 1.6, 3.15, 6.3, 12.5 and 20.0 kHz. A high-frequency auditory impairment was observed after exposure to(More)
The effects of chronic toluene exposure on central neurons were examined using syngeneic grafts into the anterior chamber of the eye. Young adult albino rats with intraocular brain transplants inhaled toluene (1000 ppm) for 9 weeks starting at the time of transplantation, or from Week 8 to 17 after the graft was placed in oculo. Control animals were exposed(More)
Rats were exposed to noise (100 dB Leq, 10 h/d, 7 d/w, 4 w), or to toluene (1,000 ppm, 16 h/d, 7 d/w, 2 w), or to noise followed by toluene. Auditory sensitivity was tested before exposure, and 1 to 4 weeks after exposure, by brainstem audiometry using a 1/3-octave filtered sine wave stimulus at the frequencies 1.6, 3.15, 6.3, 12.5 and 20.0 kHz. Some(More)
One of the most common clinical education methods for teaching patient interaction skills to nursing students is role-playing established scenarios with their classmates. Unfortunately, this is far from simulating real world experiences that they will soon face, and does not provide the immediate, impartial feedback necessary for interviewing skills(More)
Rats were exposed to toluene by inhalation (1400 ppm, 16 h/d, 8 days) and the auditory brainstem response (ABR) and distortion product otoacoustic emissions (DPOEs) were used as measures of the auditory sensitivity. These measurements were made before the exposure to toluene, 3 and 5 days after the start of the exposure and 4 days after the end of the(More)
Pigmented rats were exposed to toluene (1000 ppm, 21 h/day) for 6 or 11 weeks. The function of the vestibulo- and opto-oculomotor systems was tested one month after the end of the exposure by recording of nystagmus, induced by vestibular or optokinetic stimuli. The eye movements were recorded by a magnetic search coil technique. The optokinetic gain in the(More)
Male pigmented rats (n = 36) were exposed to toluene and/or ethanol (1000 p.p.m. toluene in the inhaled air 21 hr/day, and 5.7-8.0% ethanol in the drinking water continuously) during 8 weeks. Electrophysiological recordings were made 1 week after the exposure. Auditory sensitivity (auditory brainstem response) was reduced only after exposures including(More)