Arlene Ilagan

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BACKGROUND There is increasing concern that exposure to man-made substances that mimic endogenous hormones may adversely affect mammalian reproduction. Although a variety of reproductive complications have been ascribed to compounds with androgenic or estrogenic properties, little attention has been directed at the potential consequences of such exposures(More)
BACKGROUND It is well known that the fidelity of meiotic chromosome segregation is greatly reduced with increasing maternal age in humans. More recently, direct studies of human oocytes have demonstrated a striking age-related increase in oocytes exhibiting gross disturbances in chromosome alignment on the meiotic spindle. This abnormality, termed(More)
Ultraviolet (UV)-microbeam irradiation of a single kinetochore during anaphase generally causes all 6 of the half-bivalents in the cell to stop poleward motion within 1 min after the irradiation. The half-bivalents regain movement after remaining stopped for an average of 8.7 min, through different pairs in the same cell can resume at different times. Once(More)
We used an ultraviolet microbeam to irradiate kinetochores, or to irradiate kinetochore fibres just in front of kinetochores, in anaphase crane-fly spermatocytes. Forward movements were blocked after most irradiations, but in 7 cells the associated anaphase half-bivalents moved backward, toward their partner half-bivalents, with speeds faster than poleward(More)
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