Arjun Vadapalli

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A theoretical model is developed to investigate the influence of hemoglobin-based oxygen carriers (HBOCs) on oxygen transport in capillary-size vessels. A discrete cell model is presented with red blood cells (RBCs) represented in their realistic parachute shape flowing in a single file through a capillary. The model includes the free and Hb-facilitated(More)
A detailed computational model is developed to simulate oxygen transport from a three-dimensional (3D) microvascular network to the surrounding tissue in the presence of hemoglobin-based oxygen carriers. The model accounts for nonlinear O(2) consumption, myoglobin-facilitated diffusion and nonlinear oxyhemoglobin dissociation in the RBCs and plasma. It also(More)
Using modified oxygen needle microelectrodes and intravital videomicroscopy, measurements were made of tissue oxygen tension (PO(2)) profiles near cortical arterioles and transmural PO(2) gradients in the pial arterioles of the rat. Under control conditions, the transmural PO(2) gradient averaged 1.17+/-0.06 mm Hg/microm (mean+/-s.e., n=40). Local(More)
We describe recent models of oxygen transport in tissue along the pathway from the hemoglobin molecule to the mitochondria and illustrate their applications. Microvasculature is the major site of exchange between blood and parenchymal cells for gases (O2, CO2, CO, NO), nutrients, metabolic products, and drugs. These exchange processes are affected by the(More)
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