Learn More
Large cloud service providers have invested in increasingly larger datacenters to house the computing infrastructure required to support their services. Accordingly, researchers and industry practitioners alike have focused a great deal of effort designing network fabrics to efficiently interconnect and manage the traffic within these datacenters in(More)
We argue that controlling energy allocation is an increasingly useful and important feature for operating systems, especially on mobile devices. We present two new low-level abstractions in the Cinder operating system, <i>reserves</i> and taps, which store and distribute energy for application use. We identify three key properties of control --(More)
Arterolane (RBx 11160) maleate is a novel, rapidly acting synthetic trioxolane antimalarial compound being developed by Ranbaxy Research Laboratories (Haryana, India). It is presently under phase III in combination with piperaquine phosphate. The present work reports the relationship between pharmacokinetic (PK) parameter (AUC(0-8h) on day 0/day 6) and(More)
BACKGROUND Artemisinin-based combination therapy is the first-line treatment for uncomplicated falciparum malaria. This study assessed the antimalarial efficacy and safety of a combination of 150 mg of arterolane maleate and 750 mg of piperaquine phosphate (AM-PQP) in comparison to Coartem (artemether and lumefantrine) in patients with acute uncomplicated(More)
On the cover: Calavera of the Morbid Cholera, etching on paper, 1910, by José Guadalupe Posada (Mexican,1852–1913). Library of Congress Prints and Photographs Division Washington, D.C. USA. Public Domain. Calaveras (Spanish for skulls), have been produced in Mexico as a form of satirical art for over a hundred years, having been popularized in this use by(More)
Datacenters are characterized by their large scale,<lb>stringent reliability requirements, and significant appli-<lb>cation diversity. However, the realities of employing<lb>hardware with small but non-zero failure rates mean that<lb>datacenters are subject to significant numbers of failures,<lb>impacting the performance of the services that rely(More)
BACKGROUND Drug-resistant Plasmodium falciparum malaria necessitates development of novel drugs for treatment.The present study assessed the efficacy and safety of 3 dose levels of arterolane (RBx 11160), a synthetic trioxolane, for treatment of acute uncomplicated falciparum malaria. METHODS In this randomized, double-blind, multicenter, parallel-group,(More)
The World Health Organization (WHO) recommends artemisinin combination therapy (ACT) for the treatment of uncomplicated Plasmodium falciparum malaria. The present study investigated the efficacy and safety of fixed dose combination (FDC) of arterolane maleate 37.5 mg and piperaquine phosphate (PQP) 187.5 mg dispersible tablets in paediatric patients aged 6(More)
Researchers and practitioners alike have long relied upon emulation to evaluate the performance of networked applications and protocols without tying up production infrastructure or committing to expensive hardware purchases. As software defined networks (SDN) become more prevalent, it is increasingly useful to be able to accurately emulate their behavior.(More)
BACKGROUND Artemisinins, which are derived from plants, are subject to risk of supply interruption due to climatic changes. Consequently, an effort to identify a new synthetic antimalarial was initiated. A fixed-dose combination of arterolane maleate (AM), a new synthetic trioxolane, with piperaquine phosphate (PQP), a long half-life bisquinoline, was(More)