Arjen Amelink

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We demonstrate the capability of differential path-length spectroscopy (DPS) to determine the local optical properties of tissue in vivo. DPS measurements on bronchial mucosa are analyzed and yield information on the local blood oxygenation, blood content, average microvessel diameter, and wavelength dependence of the reduced scattering coefficient. Our(More)
Single fiber reflectance spectroscopy is a method to noninvasively quantitate tissue absorption and scattering properties. This study utilizes a Monte Carlo (MC) model to investigate the effect that optical properties have on the propagation of photons that are collected during the single fiber reflectance measurement. MC model estimates of the single fiber(More)
Differential path-length spectroscopy (DPS) was used to determine the local optical properties of breast tissue in vivo. DPS measurements were made on healthy and malignant breast tissue using a fibre-optic needle probe, and were correlated to the histological outcome of core-needle biopsies taken from the same location as the measurements. DPS yields(More)
BACKGROUND AND OBJECTIVE Foslip® and Fospeg® are liposomal formulations of the photosensitizer mTHPC, intended for use in Photodynamic Therapy (PDT) of malignancies. Foslip consists of mTHPC encapsulated in conventional liposomes, Fospeg consists of mTHPC encapsulated in pegylated liposomes. Possible differences in tumor fluorescence and vasculature(More)
INTRODUCTION Esophageal endoscopic ultrasound-guided fine needle aspiration (EUS-FNA) is a minimally invasive staging procedure for mediastinal lymph nodes in patients diagnosed with lung cancer. But, a substantial false negative rate necessitates that patients returning a negative EUS-FNA result must undergo a subsequent surgical staging procedure. This(More)
A reflectance spectroscopic device that utilizes a single fiber for both light delivery and collection has advantages over classical multi-fiber probes. This study presents a novel empirical relationship between the single fiber path length and the combined effect of both the absorption coefficient, mua (range: 0.1-6 mm-1), and the reduced scattering(More)
Differential path length spectroscopy (DPS) is a method of reflectance spectroscopy that utilizes a specialized fiber geometry to make the photon path length (tau) insensitive to variations in tissue optical properties over a wide range of absorption (mu(a)) and total scattering (mu(s)) coefficients, which are common within the ultraviolet/visible (UV/VIS)(More)
This paper presents a relationship between the intensity collected by a single fiber reflectance device (R(SF)) and the fiber diameter (d(fib)) and the reduced scattering coefficient ( μs') and phase function (p(θ)) of a turbid medium. Monte Carlo simulations are used to identify and model a relationship between R(SF) and dimensionless scattering ((More)
We describe the incorporation of a single-fiber reflectance spectroscopy probe into the endoscopic ultrasound fine-needle aspiration (EUS-FNA) procedure utilized for lung cancer staging. A mathematical model is developed to extract information about the physiological and morphological properties of lymph tissue from single-fiber reflectance spectra, e.g.,(More)
This study utilizes experimentally validated Monte Carlo simulations to identify a mathematical formulation of the reflectance intensity collected by a single fiber probe expressed in terms of the reduced scattering coefficient (μs'), fiber diameter d(fiber), and a property of the first two moments of the scattering phase function (γ). This model is then(More)