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Metabolic disposition and biological significance of simple phenols of dietary origin: hydroxytyrosol and tyrosol
TLDR
This review discusses and summarizes the state of the art of the scientific evidence regarding the processes of absorption, distribution, metabolism and excretion of both hydroxytyrosol and tyrosol, and examines the impact of these compounds and their metabolites on biological activity in terms of beneficial health effects. Expand
Ultra high performance liquid chromatography tandem mass spectrometric detection of glucuronides resistant to enzymatic hydrolysis: Implications to doping control analysis.
TLDR
The developed UHPLC-MS/MS method confirmed the potential of the resistant glucuronides as biomarkers of T misuse and suggested that previously reported reference ranges for these metabolites should be reevaluated. Expand
Untargeted metabolomics in doping control: detection of new markers of testosterone misuse by ultrahigh performance liquid chromatography coupled to high-resolution mass spectrometry.
TLDR
The in-depth study of the MS and MS/MS behavior of this marker allowed for the establishment of 1-cyclopentenoylglycine as a feasible structure, and this potential marker seems to come from the metabolism of the cypionic acid release after hydrolysis of the administered ester. Expand
Detection, synthesis and characterization of metabolites of steroid hormones conjugated with cysteine
TLDR
The analysis of urine samples collected after testosterone administration confirmed that synthesized cysteine conjugates are testosterone metabolites, indicating that the presented metabolic pathway is not exclusively active in androgens, but common to progestagens and glucocorticoids. Expand
Dose effect on the uptake and accumulation of hydroxytyrosol and its metabolites in target tissues in rats.
TLDR
Investigation of the relationship between the HT dose intake and its tissue uptake in rats showed that HT and its metabolites could be accumulated in a dose-dependent manner basically in the liver, kidney, and brain and were detected in these tissues even at nutritionally relevant human doses. Expand
Dose-dependent metabolic disposition of hydroxytyrosol and formation of mercapturates in rats.
TLDR
The results indicate that the metabolic disposition of HT is highly dependent on the dose ingested, and for the first time the formation of the mercapturate conjugate of HT in a dose-dependent manner is reported. Expand
Screening for anabolic steroids in sports: analytical strategy based on the detection of phase I and phase II intact urinary metabolites by liquid chromatography tandem mass spectrometry.
TLDR
TheLC-MS/MS screening method represents a cost-effective approach that improves the detection capabilities of AAS by increasing the sensitivity for some metabolites and by including recently described phase II long-term metabolites not detectable using the current screening strategy. Expand
Detection and characterization of clostebol sulfate metabolites in Caucasian population.
TLDR
Monitoring of S1a improves the detection time of clostebol misuse with respect to the commonly monitored metabolites, excreted in the glucuronide fraction, and this new metabolite can be incorporated into recently developed LC-MS/MS screening methods base on the direct detection of phase II metabolites. Expand
Evaluation of two glucuronides resistant to enzymatic hydrolysis as markers of testosterone oral administration
TLDR
The four markers presented seem to have an exceptional potential as biomarkers of T oral administration and were highlighted by their prolonged capacity to detect the T misuse in the case of one volunteer whose TG/EG barely exceeded his individual threshold. Expand
Evaluation of markers out of the steroid profile for the screening of testosterone misuse. Part I: Transdermal administration.
TLDR
Overall; this evaluation advises for the introduction of additional glucuronoconjugated markers in the screening of transdermal T administration. Expand
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