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INTRODUCTION At present, no disease-modifying osteoarthritis drugs (DMOADS) are approved by the FDA (US Food and Drug Administration); possibly partly due to inadequate trial design since efficacy demonstration requires disease progression in the placebo group. We investigated whether combinations of biochemical and magnetic resonance imaging (MRI)-based(More)
RATIONALE AND OBJECTIVES Cartilage loss as determined by magnetic resonance imaging (MRI) or joint space narrowing as determined by x-ray is the result of cartilage erosion. However, metabolic processes within the cartilage that later result in cartilage loss may be a more sensitive assessment method for early changes. Recently, it was shown that cartilage(More)
An inherent drawback of the traditional diffusion tensor model is its limited ability to provide detailed information about multidirectional fiber architecture within a voxel. This leads to erroneous fiber tractography results in locations where fiber bundles cross each other. This may lead to the inability to visualize clinically important tracts such as(More)
PURPOSE Intensity modulated radiation therapy (IMRT) allows greater control over dose distribution, which leads to a decrease in radiation related toxicity. IMRT, however, requires precise and accurate delineation of the organs at risk and target volumes. Manual delineation is tedious and suffers from both interobserver and intraobserver variability. State(More)
Accuracy and robustness are fundamental requirements of any automated method used for segmentation of medical images. Model-based segmentation (MBS) is a well established technique, where uncertainties in image content can be to a certain extent compensated by the use of prior shape information. This approach is, however, often problematic in cases where(More)
An inherent drawback of the traditional diffusion tensor model is its limited ability to provide detailed information about multidirectional fiber architecture within a voxel. This leads to erroneous fiber tractography results in locations where fiber bundles cross each other. In this paper, we present a deterministic two-tensor extended Streamline(More)
A study of the involvement of lips and the perioral tissues, by cutaneous leishmaniasis among 492 patients diagnosed to have been affected by the disease at a district general hospital in the Southwest highlands of Saudi Arabia over a period of 18 months is presented together with clinical and diagnostic aspects of such involvement. Differential diagnosis(More)