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Urinary Exosomal mRNA of WT1 as Diagnostic and Prognostic Biomarker for Diabetic Nephropathy.
TLDR
Urinary exosomal WT1 is a useful biomarker to improve risk stratification in patients with DN and can predict the decline in eGFR for the following several years.
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Cbl-b Is a Critical Regulator of Macrophage Activation Associated With Obesity-Induced Insulin Resistance in Mice
TLDR
Results suggest that Cbl-b deficiency could exaggerate HFD-induced insulin resistance through saturated FA-mediated macrophage activation, and inhibition of TLR4 signaling is an attractive therapeutic strategy for treatment of obesity-related insulin resistance.
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Soy Glycinin Contains a Functional Inhibitory Sequence against Muscle-Atrophy-Associated Ubiquitin Ligase Cbl-b
TLDR
Dietary soy glycinin protein significantly prevented muscle atrophy after denervation in mice, and partially suppressed the denervation-mediated expression of atrogenes, such as MAFbx/atrogin-1 and MuRF-1, through the protection of IGF-1 signaling estimated by phosphorylation of Akt-1.
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Ubiquitin ligase Cbl-b and obesity-induced insulin resistance.
TLDR
Cbl-b and c-Cbl are potential therapeutic targets for treating obesity-induced insulin resistance and the importance of Cbl- b in macrophage activation in aging-induced and high-fat diet-induced obesity is focused on.
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Involvement of Elf3 on Smad3 activation-dependent injuries in podocytes and excretion of urinary exosome in diabetic nephropathy
TLDR
The rate of decline in the estimated Glomerular Filtration Rate (eGFR) after measurement of urinary exosomal Elf3 protein levels in patients with DN might be useful as an early non-invasive marker for podocyte injuries in DN.
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Novel Interplay Between Smad1 and Smad3 Phosphorylation via AGE Regulates the Progression of Diabetic Nephropathy
TLDR
Results indicate that Smad3 expression and activation or probucol treatment alters Smad1 phosphorylation, thus suggesting new molecular mechanisms underlying DN development and progression.
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Isoflavones derived from soy beans prevent MuRF1-mediated muscle atrophy in C2C12 myotubes through SIRT1 activation.
TLDR
The results suggest that isoflavones suppress myotube atrophy in skeletal muscle cells through activation of SIRT1 signaling, which could provide a novel therapeutic approach against inflammation-related muscle atrophy.
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Effects of dietary soy protein on skeletal muscle volume and strength in humans with various physical activities.
TLDR
The supplementation of soy protein would be one of the effective foods which prevent the skeletal muscle atrophy caused by immobilization or unloading.
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N-myristoylated ubiquitin ligase Cbl-b inhibitor prevents on glucocorticoid-induced atrophy in mouse skeletal muscle.
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Prevention of skeletal muscle atrophy in vitro using anti-ubiquitination oligopeptide carried by atelocollagen.
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