Arifullah Khan

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The crude extract of Fumaria indica whole plant (Fi.Cr) and its fractions were studied in vitro for spasmogenic and spasmolytic effects to rationalize some of the traditional uses. Fi.Cr (1.0-5.0 mg/mL) caused a moderate degree of atropine-sensitive spasmogenic effect in guinea-pig ileum. In spontaneously contracting rabbit jejunum, Fi.Cr (0.03-0.3 mg/mL)(More)
Neutralization of bacterial cell surface potential using nanoscale materials is an effective strategy to alter membrane permeability, cytoplasmic leakage, and ultimate cell death. In the present study, an attempt was made to prepare biogenic silver nanoparticles using biomolecules from the aqueous rhizome extract of Coptis Chinensis. The biosynthesized(More)
Cyclophilins are a family of cyclosporin-A-binding proteins which catalyse rotation about prolyl peptide bonds. A mitochondrial isoform in mammalian cells, cyclophilin D, is a component of the permeability transition pore that is formed by the adenine nucleotide translocase and the voltage-dependent anion channel at contact sites between the inner and outer(More)
In Acholeplasma laidlawii membranes the ratio between the dominating lipids, monoglucosyldiglyceride (MGDG) and diglucosyldiglyceride (DGDG), depends on temperature, configuration of incorporated fatty acids, and membrane cholesterol content, which affect the molecular geometry of the lipids. MGDG and DGDG have wedge- and rod-like molecular shapes,(More)
The phase equilibria in four lysophosphatidylcholine/water systems were investigated at different temperatures. Each of the 1-palmitoyl-, 1-stearoyl-, 1-oleoyl- and 1-linoleoyl-sn-glycero-3-phosphocholines was dispersed in heavy water at different concentrations. The phase structures were determined by 2H-, 14N- and 31P-NMR, polarization microscopy and(More)
1. The packing properties in lipid mixtures containing cholesterol and membrane glucolipids from Acholeplasma laidlawii are modified by varying the amounts of cholesterol, diacylmonoglucosylglycerol and diacyldiglucosylglycerol in the mixtures as well as the temperature and the degree of acyl chain unsaturation. These changes affect both the proportions of(More)
The antimicrobial activities of Circium arvense extracts were evaluated against two human gram positive (Staphylococcus aureus, Micrococcus luteus) and four gram negative pathogen (Escherichia coli, pseudomonas aeruginosa, Enterobacter, Klebsiella pneumoniae). The Methanol extracts of Circium arvense were used to obtain various fractions (X1) n-hexane, (X2)(More)
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