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Structural basis of androgen receptor binding to selective androgen response elements.

• Paul L. Shaffer, Arif Jivan, D Eric Dollins, Frank Claessens, Daniel T Gewirth
• Proceedings of the National Academy of Sciences…
• 2004

Steroid receptors bind as dimers to a degenerate set of response elements containing inverted repeats of a hexameric half-site separated by 3 bp of spacer (IR3). Naturally occurring selective… (More)

Structure of the N-terminal domain of GRP94. Basis for ligand specificity and regulation.

• Karen L Soldano, Arif Jivan, Christopher V Nicchitta, Daniel T Gewirth
• The Journal of biological chemistry
• 2003

GRP94, the endoplasmic reticulum (ER) paralog of the chaperone Hsp90, plays an essential role in the structural maturation or secretion of a subset of proteins destined for transport to the cell… (More)

The G protein-coupled taste receptor T1R1/T1R3 regulates mTORC1 and autophagy.

• Eric M. Wauson, Elma Zaganjor, +9 authors Melanie H Cobb
• Molecular cell
• 2012

Cells continually assess their energy and nutrient state to maintain growth and survival and engage necessary homeostatic mechanisms. Cell-autonomous responses to the fed state require the… (More)

Radial spoke protein 3 is a mammalian protein kinase A-anchoring protein that binds ERK1/2.

• Arif Jivan, Svetlana Earnest, Yu-Chi Juang, Melanie H Cobb
• The Journal of biological chemistry
• 2009

Initially identified in Chlamydomonas, RSP3 (radial spoke protein 3) is 1 of more than 20 identified radial spoke structural components of motile cilia and is required for axonemal sliding and… (More)

The roles of MAPKs in disease

• Michael C Lawrence, Arif Jivan, +9 authors Melanie H Cobb
• Cell Research
• 2008

MAP kinases transduce signals that are involved in a multitude of cellular pathways and functions in response to a variety of ligands and cell stimuli. Aberrant or inappropriate functions of MAPKs… (More)

Reconstitution of the nuclear transport of the MAP kinase ERK2.

• Arif Jivan, Aarati Ranganathan, Melanie H Cobb
• Methods in molecular biology
• 2010

The nuclear-cytoplasmic distribution of ERK2 is regulated in response to various stimuli and changes in cell context. Furthermore, the nuclear flux of ERK2 occurs by several energy- and… (More)

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