Arielle Hunter

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We evaluated the influence of gender on penetrance of GTP-cyclohydrolase I (GCH) gene mutations in hereditary progressive dystonia/dopa-responsive dystonia (HPD/DRD) and determined whether some apparently sporadic HPD/DRD patients owe their disorder to a de novo mutation of the GCH gene. Previous clinical investigations of HPD/DRD have shown a predominance(More)
OBJECTIVES Chemoradiation is the treatment of choice for squamous carcinoma of the anal canal, resulting in the same local control rates as surgery but with the advantage of organ function preservation. We aimed to review all cases of anal canal carcinoma treated at Groote Schuur Hospital between 2000 and 2004 and to assess treatement outcome. METHODS The(More)
UNLABELLED Measurement of segmental colonic transit is important in the assessment of patients with severe constipation. 111In-diethylenetriamine pentaacetic acid (DTPA) has been established as the tracer of choice for these studies, but it is expensive and not readily available. 67Ga-citrate is an inexpensive tracer and when given orally is not absorbed(More)
Passive avoidance training has been shown to cause an increase in synaptic density (Nvsyn) in the lobus parolfactorius (LPO) of the one-day old chick. The present study was conducted to investigate the time-course over which this plastic change takes place. Two groups of chicks were trained to peck at either a water coated bead (Control) or a(More)
OBJECTIVES To characterise mucins in cancer of the colon and compare these with controls using stringent biochemical measures to avoid endogenous proteolysis. DESIGN Crude mucus scrapings were collected from 12 specimens obtained by colectomy. Specimens from 3 traumatic colectomies and 1 sigmoid volvulus were used as controls, and compared with 6(More)
................................................................................................................................. xi CHAPTER 1: GENERAL INTRODUCTION............................................................................ 1 The SPS Amino Acid Sensing Pathway in Yeast ................................................................. 1(More)
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