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TMEM258 Is a Component of the Oligosaccharyltransferase Complex Controlling ER Stress and Intestinal Inflammation.
- Daniel B Graham, Ariel Lefkovith, +14 authors R. Xavier
- Biology, Chemistry
- Cell reports
- 1 December 2016
Significant insights into disease pathogenesis have been gleaned from population-level genetic studies; however, many loci associated with complex genetic disease contain numerous genes, and… Expand
Antigen discovery and specification of immunodominance hierarchies for MHCII-restricted epitopes
Identifying immunodominant T cell epitopes remains a significant challenge in the context of infectious disease, autoimmunity, and immuno-oncology. To address the challenge of antigen discovery, we… Expand
Transcriptional Atlas of Intestinal Immune Cells Reveals that Neuropeptide α-CGRP Modulates Group 2 Innate Lymphoid Cell Responses.
Signaling abnormalities in immune responses in the small intestine can trigger chronic type 2 inflammation involving interaction of multiple immune cell types. To systematically characterize this… Expand
Cell Type– and Stimulation-Dependent Transcriptional Programs Regulated by Atg16L1 and Its Crohn's Disease Risk Variant T300A
Key Points Stimulation-based profiling defined genotype- and cell-specific Atg16L1 programs. Cell type and stimulation strongly influence Atg16L1 T300A genotypic differences. Genotype- and… Expand
University of Groningen TMEM 258 Is a Component of the Oligosaccharyltransferase Complex Controlling ER Stress and Intestinal Inflammation
A missense variant in SLC39A8 confers risk for Crohn’s disease by disrupting manganese homeostasis and intestinal barrier integrity
- T. Nakata, E. Creasey, +7 authors R. Xavier
- Proceedings of the National Academy of Sciences
- 2 November 2020
Significance SLC39A8 A391T exhibits remarkable pleiotropic effects on multiple conditions, including cardiovascular diseases, Parkinson’s disease, and Crohn’s disease. However, how this single coding… Expand