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  • Ariel C. Bulua, Anna Simon, +6 authors Richard M. Siegel
  • Biology, Medicine
  • The Journal of experimental medicine
  • 2011 (First Publication: 14 March 2011)
  • ROS generated by mitochondrial respiration are needed for optimal proinflammatory cytokine production in healthy cells, and are elevated in cells from patients with an autoinflammatory disorder.
  • Anna Katharina Simon, Heiyoung Park, +10 authors Richard M. Siegel
  • Medicine, Biology
  • Proceedings of the National Academy of Sciences
  • 2010 (First Publication: 10 May 2010)
  • TNF, acting through p55 tumor necrosis factor receptor 1 (TNFR1), contributes to the pathogenesis of many inflammatory diseases. TNFR-associated periodic syndrome (TRAPS, OMIM 142680) is an autosomalContinue Reading
  • Ariel C. Bulua, Douglas B Mogul, +8 authors Keith M. Hull
  • Medicine
  • Arthritis and rheumatism
  • 2012 (First Publication: 1 March 2012)
  • OBJECTIVE To investigate the efficacy of etanercept in improving the symptoms and underlying inflammation in patients with tumor necrosis factor receptor-associated periodic syndrome (TRAPS). Continue Reading
  • James E. Balow, John Gerard Ryan, +9 authors Ivona Aksentijevich
  • Medicine
  • Annals of the rheumatic diseases
  • 2013 (First Publication: 5 December 2012)
  • Objective To analyse gene expression patterns and to define a specific gene expression signature in patients with the severe end of the spectrum of cryopyrin-associated periodic syndromes (CAPS). TheContinue Reading