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Continuous, real-time monitoring of cocaine in undiluted blood serum via a microfluidic, electrochemical aptamer-based sensor.
The approach of integrating folding-based electrochemical sensors with miniaturized detection systems may lay the groundwork for the real-time, point-of-care detection of a wide variety of molecular targets. Expand
Folding-based electrochemical biosensors: the case for responsive nucleic acid architectures.
A broad new class of biosensors are developed that employ electrochemistry to monitor binding-induced changes in the rigidity of a redox-tagged probe DNA that has been site-specifically attached to an interrogating electrode. Expand
Single-step electronic detection of femtomolar DNA by target-induced strand displacement in an electrode-bound duplex
A signal-on, electronic DNA (E-DNA) sensor that is label-free and achieves a subpicomolar detection limit and appears to provide a ready alternative to the more cumbersome femtomolar electrochemical assays described to date. Expand
Effects of probe length, probe geometry, and redox-tag placement on the performance of the electrochemical E-DNA sensor.
Previous work has described several reagentless, electrochemical DNA (E-DNA) sensing architectures comprised of an electrode-immobilized, redox-tagged probe oligonucleotide. Recent studies suggestExpand
Optimization of electrochemical aptamer-based sensors via optimization of probe packing density and surface chemistry.
It is demonstrated that fabrication and operational parameters can be varied to achieve optimal sensor performance and that these can serve as a basic outline for future sensor fabrication. Expand
Sequence-specific, electronic detection of oligonucleotides in blood, soil, and foodstuffs with the reagentless, reusable E-DNA sensor.
E-DNA is selective enough to detect oligonucleotides in complex, multicomponent samples, such as blood serum and soil, and its utility as a rapid, specific, and convenient method for the detection of DNA and RNA sequences is supported. Expand
Label-free, dual-analyte electrochemical biosensors: a new class of molecular-electronic logic gates.
An "XOR" gate built using label-free, dual-analyte electrochemical sensors and the activation of this logic gate via changing concentrations of cocaine and the relevant cDNA as inputs are described.
Electrochemical biosensors employing an internal electrode attachment site and achieving reversible, high gain detection of specific nucleic acid sequences.
This work reports the development of a signal-on E-DNA architecture that achieves both high signal gain and good stability, and employs a commercially synthesized, asymmetric hairpin DNA as its recognition and signaling probe. Expand
Chimeric peptide beacons: a direct polypeptide analog of DNA molecular beacons.
A new biosensor architecture, which is comprised of a polypeptide- peptide nucleic acid tri-block copolymer and which is termed chimeric peptide beacons (CPB), that generates an optical output via a mechanism analogous to that employed in DNA-based molecular beacons. Expand