Ariana Frederick

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Circadian rhythms modulate behavioral processes over a 24 h period through clock gene expression. What is largely unknown is how these molecular influences shape neural activity in different brain areas. The clock gene Per2 is rhythmically expressed in the striatum and the cerebellum and its expression is linked with daily fluctuations in extracellular(More)
Background: Bone generation during fracture healing has been demonstrated repeatedly and yet the generation of articular cartilage and joints remains an elusive goal. It has long been recognized that the rigidity of fracture fixation can be correlated with the extent to which either the endochondral or intramembranous mechanisms of callus formation(More)
BACKGROUND Spinal cord compression is a known cause of spinal cord injury. The purpose of this study is to measure pressure response during graded spinal cord compression. This information will be important in evaluating the amount of canal compromise that can be tolerated before risking neurological injury secondary to cord compression. To date, there is(More)
Despite rhythmic expression of clock genes being found throughout the central nervous system, very little is known about their function outside of the suprachiasmatic nucleus. Determining the pattern of clock gene expression across neuronal subpopulations is a key step in understanding their regulation and how they may influence the functions of various(More)
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