Ari Zeida

Publications29
h-index9
Citations243
Highly Influential Citations8
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The extraordinary catalytic ability of peroxiredoxins: a combined experimental and QM/MM study on the fast thiol oxidation step.
Peroxiredoxins (Prxs) catalyze the reduction of peroxides, a process of key relevance in a variety of cellular processes. The first step in the catalytic cycle of all Prxs is the oxidation of a… Expand
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Comparative Analysis of Hydrogen Peroxide and Peroxynitrite Reactivity with Thiols
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Molecular basis of the mechanism of thiol oxidation by hydrogen peroxide in aqueous solution: challenging the SN2 paradigm.
The oxidation of cellular thiol-containing compounds, such as glutathione and protein Cys residues, is considered to play an important role in many biological processes. Among possible oxidants,… Expand
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PrxQ B from Mycobacterium tuberculosis is a monomeric, thioredoxin-dependent and highly efficient fatty acid hydroperoxide reductase.
Mycobacterium tuberculosis (M. tuberculosis) is the intracellular bacterium responsible for tuberculosis disease (TD). Inside the phagosomes of activated macrophages, M. tuberculosis is exposed to… Expand
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Catalysis of Peroxide Reduction by Fast Reacting Protein Thiols.
Life on Earth evolved in the presence of hydrogen peroxide, and other peroxides also emerged before and with the rise of aerobic metabolism. They were considered only as toxic byproducts for many… Expand
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Commentary on “Using resonance synchronous spectroscopy to characterize the reactivity and electrophilicity of biologically relevant sulfane sulfur”. Evidence that the methodology is inadequate…
a Laboratorio de Enzimología, Instituto de Química Biológica, Facultad de Ciencias, Universidad de la República, Montevideo, 11400, Uruguay b Centro de Investigaciones Biomédicas, Universidad de la… Expand
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Insights into the mechanism of the reaction between hydrogen sulfide and peroxynitrite.
Hydrogen sulfide and peroxynitrite are endogenously generated molecules that participate in biologically relevant pathways. A revision of the kinetic features of the reaction between peroxynitrite… Expand
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Mechanism of cysteine oxidation by peroxynitrite: An integrated experimental and theoretical study.
Since peroxynitrite was identified as a pathophysiological agent it has been implicated in a great variety of cellular processes. Particularly, peroxynitrite mediated oxidation of cellular… Expand
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Improving Efficiency in SMD Simulations Through a Hybrid Differential Relaxation Algorithm.
TLDR
We present and thoroughly test a hybrid differential relaxation algorithm (HyDRA), which allows faster equilibration of the classical environment during the nonequilibrium steering of a (bio)chemical reaction. Expand
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Thiol redox biochemistry: insights from computer simulations
Thiol redox chemical reactions play a key role in a variety of physiological processes, mainly due to the presence of low-molecular-weight thiols and cysteine residues in proteins involved in… Expand
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