Ari M Grinspan

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exome sequencing studies of sporadic tumors, this discovery is noteworthy in that it provides a new and rational target for investigation. IPMK is an inositol phosphate kinase, and the authors describe a link between IPMK and p53-mediated apoptosis. It will be important to understand the importance of this interaction in the context of homeostasis and(More)
Ulcerative colitis (UC) is a chronic inflammatory condition of the colon, characterized by diffuse mucosal inflammation, bloody diarrhea, and urgency. The mainstay of treatment has been mesalamine agents, steroids, thiopurines, and anti-tumor necrosis factor alpha (TNF-α) antibodies. Over the past several years, new therapies have emerged which have(More)
BACKGROUND & AIMS It is not clear how the complex interactions between diet and the intestinal microbiota affect development of mucosal inflammation or inflammatory bowel disease. We investigated interactions between dietary ingredients, nutrients, and the microbiota in specific pathogen-free (SPF) and germ-free (GF) mice given more than 40 unique diets; we(More)
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