Ari D. Brettman

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Despite rapid advances in the genetics of complex human diseases, understanding the significance of human disease alleles remains a critical roadblock to clinical translation. Here, we present a chemical biology approach that uses perturbation with small molecules of known mechanism to reveal mechanistic and therapeutic consequences of human disease(More)
S tudies of the genetics of cardiovascular disease and its risk factors have identified many chromosomal loci that contribute to cardiovascular traits. When combining the outcomes of these studies with the findings from basic, hypothesis-driven research, we now have a much clearer outline of the genes that contribute to cardiovascular traits (the parts(More)
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