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  • Arendien Hoogerkamp, Renate Arends, A M Bomers, Jaap W. Mandema, Rob A. Voskuyl, Meindert Danhof
  • Chemistry, Medicine
  • The Journal of pharmacology and experimental…
  • 1996 (First Publication: 1 November 1996)
  • The in vivo concentration-anticonvulsant effect relationships of six benzodiazepines, midazolam, clonazepam, oxazepam, flunitrazepam, diazepam and clobazam were quantified in individual rats andExpand
  • Arendien Hoogerkamp, Paul W. Riem Vis, Meindert Danhof, Rob A. Voskuyl
  • Chemistry, Medicine
  • The Journal of pharmacology and experimental…
  • 1994 (First Publication: 1 May 1994)
  • In this investigation a newly developed direct cortical stimulation technique was evaluated for measurement of anticonvulsant efficacy in rats. The kinetics of drug action for carbamazepine,Expand
  • Oscar E. Della Paschoa, Arendien Hoogerkamp, Peter M. Edelbroek, Rob A. Voskuyl, Meindert Danhof
  • Psychology, Medicine
  • Epilepsy Research
  • 2000 (First Publication: 1 June 2000)
  • The purpose of this study was to assess the concentration-anti-convulsant effect relationships of a number of anti-convulsant drugs in the direct cortical stimulation model, to obtain more insight inExpand
  • Meindert Danhof, Jaap W. Mandema, Arendien Hoogerkamp, Ron A. A. Mathôt
  • Medicine, Chemistry
  • European Journal of Drug Metabolism and…
  • 2011 (First Publication: 1 March 1993)
  • SummaryA new approach to preclinical pharmacodynamic investigations is presented which allows, in addition to information on the nature of the pharmacological properties of new chemical entities,Expand
  • Annemiek M. Stijnen, Suzanne Hovinga, Mariska W. E. Langemeijer, Arendien Hoogerkamp, C F van Bezooijen, Meindert Danhof
  • Chemistry, Medicine
  • Pharmaceutical Research
  • 1993 (First Publication: 1 July 1993)
  • The aim of the present investigations was to study the influence of increasing age on the pharmacodynamics of valproate in BN/BiRij rats, applying a threshold for electrically induced localizedExpand