Aravind Chandrasekaran

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Speaker recognition/verification systems require an extensive universal background model (UBM), which typically requires extensive resources, especially if new channel domains are considered. In this study we propose an effective and computationally efficient algorithm for training the UBM for speaker verification. A novel method based on Euclidean distance(More)
We provide evidence supporting that protein-protein and protein-ligand docking poses are functions of protein shape and intrinsic dynamics. Over sets of 68 protein-protein complexes and 240 nonhomologous enzymes, we recognize common predispositions for binding sites to have minimal vibrations and angular momenta, while two interacting proteins orient so as(More)
Structure-encoded conformational dynamics are crucial for biomolecular functions. However, there is insufficient evidence to support the notion that dynamics play a role in guiding protein-nucleic acid interactions. Here, we show that protein-DNA docking orientation is a function of protein intrinsic dynamics, but the binding site itself does not display(More)
BACKGROUND A total of 17,000 patients receive kidney transplants each year in the United States. The 30-day readmission rate for kidney transplant recipients is over 30%. Our research focuses on the relationship between the quality of care delivered during the patient's hospital stay for a kidney transplant, and the patient health outcomes and readmissions(More)
The quality of operational processes is an important driver of hospital performance. In particular, processes that reliably deliver both evidence-based and patient-centered care, which we refer to conformance and experiential quality, respectively, have been argued to result in better clinical outcomes. However, hospitals, in general, struggle to perform(More)
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