Aravind Chandrasekaran

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Speaker recognition/verification systems require an extensive universal background model (UBM), which typically requires extensive resources, especially if new channel domains are considered. In this study we propose an effective and computationally efficient algorithm for training the UBM for speaker verification. A novel method based on Euclidean distance(More)
We provide evidence supporting that protein-protein and protein-ligand docking poses are functions of protein shape and intrinsic dynamics. Over sets of 68 protein-protein complexes and 240 nonhomologous enzymes, we recognize common predispositions for binding sites to have minimal vibrations and angular momenta, while two interacting proteins orient so as(More)
1. Introduction Scholarly progress can be defined as the advancement or exchange of ideas (adapted from wordnet.princeton.edu). Scholarship involves the progressive creation and exchange of knowledge that cumulates over time. Much of our current knowledge has been developed from the Shoulders of Giants from the past (Merton, 1965). That is, ''science is by(More)
Structure-encoded conformational dynamics are crucial for biomolecular functions. However, there is insufficient evidence to support the notion that dynamics play a role in guiding protein-nucleic acid interactions. Here, we show that protein-DNA docking orientation is a function of protein intrinsic dynamics, but the binding site itself does not display(More)
The quality of operational processes is an important driver of hospital performance. In particular, processes that reliably deliver both evidence-based and patient-centered care, which we refer to conformance and experiential quality, respectively, have been argued to result in better clinical outcomes. However, hospitals, in general, struggle to perform(More)
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