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Isolation of the Pyrrolizidine Alkaloid Intermedine-N-oxide from Cerinthe glabra and ab initio Calculation of its 13C NMR Shifts
The pyrrolizidine alkaloid intermedine-N-oxide was isolated from Cerinthe glabra for the first time. Due to the questionable assignments of NMR signals of this compound in previous literature reportsExpand
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Two new antileishmanial diketopiperazine alkaloids from the endophytic fungus Trichosporum sp.
The fungus Trichosporum sp. is an endophytic fungus isolated from seeds of Trigonella foenum-graecum (Fabaceae). The endophytic fungus Trichosporum sp. has been subjected to chemical and biologicalExpand
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Cytotoxicity, protein kinase inhibitory activity, and docking studies of secondary metabolites isolated from Brownea grandiceps Jacq
Background: Numerous kinases are excessively secreted in cancer. Consequently, inhibition of kinase enzymes has a basic role in the treatment of cancer through suppression or prevention of cancerExpand
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Docking Studies and Antiprotozoal Activity of Secondary Metabolites Isolated from Scrophularia Syriaca Benth. Growing in Saudi Arabia
Phytochemical study of the ethanolic extract of Scrophularia syriaca Benth. was attained by chromatographic and spectroscopic procedures, which resulted in the isolation of eight compounds;Expand
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Evaluation and understanding the molecular basis of the antimethicillin-resistant Staphylococcus aureus activity of secondary metabolites isolated from Lamium amplexicaule
Background: The genus Lamium includes about forty annual or perennial plants distributed everywhere, it has significant biological activities including antimicrobial, antioxidant and antischistosomalExpand
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Enhanced full-thickness wound healing via Sophora gibbosa extract delivery based on a chitosan/gelatin dressing incorporating microemulsion.
There are many synthetic drugs in literature have been utilized in healing of the wounds although the natural product specially antioxidants can offer similar if not better biological activity inExpand
Phytochemical and Pharmacological Evaluations of Ethanolic Extract of Bassia eriophora
Bassia eriophora (Schrad.) Asch. is one of the major and widely distributed wild plants belonging to family Chenopodiaceae and growing in northern Saudi Arabia. In this study, Phytochemical andExpand
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Insights Studies for Certain Natural FDA Approved Polyphenolics and Repurposing for COVID-19
Natural polyphenolic drugs were approved for treatment of various diseases Diosmin, rutin, quercetin, aesculin, genistein, hesperidin and silybin are known for their safety and have been applied forExpand
Morpholine-based chalcones as dual-acting monoamine oxidase-B and acetylcholinesterase inhibitors: synthesis and biochemical investigations.
Nine compounds (MO1-MO9) containing the morpholine moiety were assessed for their inhibitory activities against monoamine oxidases (MAOs) and acetylcholinesterase (AChE). Most of the compoundsExpand
Design, Synthesis, and Biological Evaluation of Pyridazinones Containing the (2-Fluorophenyl) Piperazine Moiety as Selective MAO-B Inhibitors
Twelve pyridazinones (T1–T12) containing the (2-fluorophenyl) piperazine moiety were designed, synthesized, and evaluated for monoamine oxidase (MAO) -A and -B inhibitory activities. T6 was found toExpand