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From ancient times, Swarnabhasma (gold ash) has been used in several clinical manifestations including loss of memory, defective eyesight, infertility, overall body weakness and incidence of early aging. Swarnabhasma has been used by Ayurvedic physicians to treat different diseases like bronchial asthma, rheumatoid arthritis, diabetes mellitus, nervous(More)
Ayurvedic preparations of metallic iron commonly categorised as different 'putas' of 'Louha Bhasma' was chemically analysed and pharmacologically investigated in iron deficiency anemia. Atomic absorption spectral (AAS) study of different putas of Louha Bhasma revealed the presence of various proportions of important metals along with varied concentration of(More)
Metaxalone is a skeletal muscle relaxant, an approved drug for pain relief. Published bioanalytical methods lacked detailed stability evaluation in blood and plasma. An accurate, precise, high-throughput tandem mass spectroscopic method has been developed and validated. Following solid phase extraction (SPE), metaxalone and the internal standard(More)
Sensitive and selective analytical method is required for the estimation of ramipril in human plasma as ramipril has been reported to have high intra-subject variability and phase II inactive metabolite (ramipril acyl glucuronide) back-converted to ramipril in an in vitro system. If this back conversion is not restricted, it could lead to pseudo estimation(More)
A bioanalytical method was developed and validated to estimate donepezil, 6-desmethyl donepezil and 5-desmethyl donepezil simultaneously in human plasma using galantamine as an internal standard (IS). The chromatographic separation was achieved on a reverse-phase XTerra RP (150 × 4.6 mm, 5 µm) column without affecting recovery (mean recovery > 60% with CV <(More)
Terbinafine, a widely used antifungal drug, is a challenging molecule for quantitative bioanalysis due to certain factors contributing assay variability. Despite previous attempts at human plasma determination of terbinafine, exhaustive stability of the drug or an internal standard was lacking. Internal standard stability with negligible variation(More)
OBJECTIVE To evaluate the pregnancy outcomes of all patients who underwent electrosurgical cone biopsy of the cervix between January 2000 and December 2011 and subsequently became pregnant. STUDY DESIGN Retrospective cohort study. SETTINGS District General Hospital in the North East of England. METHODS Patients were identified from the local(More)
A 36-year-old, previously healthy, parous woman was admitted as a gynaecological emergency with an 8-day history of dull and constant pain in the left lower abdomen. The onset was insidious. The pain was associated with constipation, radiated to the small of the back and was aggravated by movement. The woman complained of loss of appetite and there was no(More)