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In neurons, transport of a subset of mRNAs to subcellular regions and their translation has a role in synaptic plasticity. Recent studies have suggested a control mechanism of this local translation through mRNA compartmentalization or degradation. Here we report that processing bodies (P-bodies), which are involved in mRNA degradation or storage, are(More)
Jun-Young Oh, Ara Kwon, Anna Jo, Hoon Kim, Yong-Sook Goo, Jin-A Lee, Hyong Kyu Kim a Department of Medicine and Microbiology, College of Medicine, Signaling Disorder Research Center, Chungbuk National University, Cheongju, 361-763, The Republic of Korea b Department of Emergency Medicine, College of Medicine, Chungbuk National University, Cheongju, 361-763,(More)
Although the roles of p21-activated serine/threonine kinase 1 (PAK1) have been reported in some neurodegenerative diseases, details regarding neurodegeneration are still limited. Hence, we tried to determine the role of PAK1 and molecular mechanisms of neuronal death involved in neurodegeneration. Expression of a dominant-negative form of PAK1 (PAK1H83,86L,(More)
Antiangiogenic agents have been widely investigated in combination with standard chemotherapy or targeted cancer agents for better management of advanced cancers. Therapeutic agents that concurrently inhibit epidermal growth factor receptor and other angiokinases could be useful alternatives to combination therapies for epidermal growth factor(More)
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