Aquiles Assunção Camelier

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Alpha-1 antitrypsin deficiency is a recently identified genetic disease that occurs almost as frequently as cystic fibrosis. It is caused by various mutations in the SERPINA1 gene, and has numerous clinical implications. Alpha-1 antitrypsin is mainly produced in the liver and acts as an antiprotease. Its principal function is to inactivate neutrophil(More)
The present cross-sectional, population-based study was designed to evaluate the performance of the FEV1/FEV6 ratio for the detection of airway-obstructed subjects compared to the FEV1/FVC <0.70 fixed ratio test, as well as the lower limit of normality (LLN) for 1000 subjects (3)40 years of age in the metropolitan area of São Paulo, SP, Brazil. After the(More)
OBJECTIVE The objective of this study was to evaluate the applicability of a modified version of the Saint George's Respiratory Questionnaire. The version evaluated elicits "agree" and "do not agree", rather than "yes" and "no", responses. The intention is to facilitate the comprehension of double-negative questions and to promote better recollection of(More)
Chronic obstructive pulmonary disease (COPD) is now a major public health concern; deaths attributable to COPD in Latin America have increased by 65.0% in the last decade. This study was aimed at evaluating COPD prevalence and associated factors in adults (> 40 years) living in Greater Metropolitan São Paulo, Brazil. The study is part of the Proyecto(More)
INTRODUCTION Smoking is a serious worldwide public health problem. Animal models act as a bridge between laboratory and human studies. The models applied are difficult to reproduce because of the use of different types of inhalation chambers and mainly because of the lack of continuous monitoring of smoke concentration. OBJECTIVE To develop an inhalation(More)
OBJECTIVE To evaluate the discriminative properties and validity of the Airways Questionnaire 20 (AQ20) in a sample of patients with airway obstruction and to compare its properties with those of the St George's Respiratory Questionnaire (SGRQ) and the Short Form 36 (SF-36). PATIENTS AND METHODS A convenience sample of 47 subjects was recruited from among(More)
This study describes the correlations and reproducibility of AQ20, a simple health status questionnaire with 20 questions, which was designed to be useful especially in time sparing situations. A formal language validation process was done, in order to validate the AQ20 before studying its reproducibility. Thirty stable COPD patients answered the final(More)
Chronic obstructive pulmonary disease (COPD) is a common disease in adults over 40 years of age and has a great social and economic impact. It remains little recognized and undertreated even in developed countries. However, there are no data about its diagnosis and treatment in Brazil. The objectives of the present study were to evaluate the proportion of(More)
OBJECTIVE To evaluate the effects of the inhaled flunisolide upon the strength and endurance of the respiratory and peripheral muscles of normal subjects. DESIGN A randomized, double blind and placebo-controlled study. SETTING A university-affiliated teaching hospital. PARTICIPANTS Thirteen normal volunteers selected from a graduation course. (More)
OBJECTIVE This article presents the results of a cross-cultural reproducibility and test-retest reliability study of a Brazilian version of the Role Checklist, in a population with chronic obstructive pulmonary disease (COPD). METHODS The English version was translated and culturally adapted into Brazilian Portuguese, then administered twice at a 2-week(More)