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Resveratrol restored Nrf2 function, reduced renal inflammation, and mitigated hypertension in spontaneously hypertensive rats.
Compelling evidence supports the role of oxidative stress and renal interstitial inflammation in the pathogenesis of hypertension. Resveratrol is a polyphenolic stilbene, which can lower oxidativeExpand
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Defective nitric oxide production impairs angiotensin II-induced Na-K-ATPase regulation in spontaneously hypertensive rats.
Angiotensin (ANG) II via ANG II type 1 receptors (AT1R) activates renal sodium transporters including Na-K-ATPase and regulates sodium homeostasis and blood pressure. It is reported that at a highExpand
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Antioxidant resveratrol restores renal sodium transport regulation in SHR
Previously we have shown that in spontaneously hypertensive rats (SHR) renal angiotensin (Ang) II receptor (AT1R) upregulation leads to overstimulation of Na/K‐ATPase by Ang II. There are reportsExpand
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Resveratrol restored Nrf 2 function , reduced renal inflammation , and mitigated hypertension in spontaneously hypertensive rats
Apurva A. Javkhedkar, Yasmir Quiroz, Bernardo Rodriguez-Iturbe, Nosratola D. Vaziri, Mustafa F. Lokhandwala, and Anees A. Banday Heart and Kidney Institute, College of Pharmacy, University ofExpand
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protective effects of resveratrol against renal inflammation , oxidative stress , and development of hypertension in the SHR
Apurva A. Javkhedkar, Yasmir Quiroz, Bernardo Rodriguez-Iturbe, Nosratola D. Vaziri, Mustafa F. Lokhandwala, and Anees A. Banday Heart and Kidney Institute, College of Pharmacy, University ofExpand