Protein-protein interaction networks are typically built with interactions collated from many experiments. These networks are thus composite and show all interactions that are currently known to occur in a cell. However, these representations are static and ignore the constant changes in protein-protein interactions. Here we present software for the… (More)
Date hub proteins have 1 or 2 interaction interfaces but many interaction partners. This raises the question of whether all partner proteins compete for the interaction interface of the hub or if the cell carefully regulates aspects of this process? Here, we have used real-time rendering of protein interaction networks to analyse the interactions of all the… (More)
GEOMI is a network visualisation and analysis platform that allows interactive navigation in 3D space. We have extended the functionality of GEOMI to generate integrated visualisations of transcriptomic and proteomic data, which have provided novel insights into the dynamics of the interactome.