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A transcriptional switch underlies commitment to sexual development in malaria parasites
The life cycles of many parasites involve transitions between disparate host species, requiring these parasites to go through multiple developmental stages adapted to each of these specializedExpand
A cascade of DNA binding proteins for sexual commitment and development in Plasmodium
Commitment to and completion of sexual development are essential for malaria parasites (protists of the genus Plasmodium) to be transmitted through mosquitoes. The molecular mechanism(s) responsibleExpand
Site-specific genome editing in Plasmodium falciparum using engineered zinc-finger nucleases
Malaria afflicts over 200 million people worldwide, and its most lethal etiologic agent, Plasmodium falciparum, is evolving to resist even the latest-generation therapeutics. Efficient tools forExpand
The C. elegans adult neuronal IIS/FOXO transcriptome reveals adult phenotype regulators
Insulin/insulin-like growth factor signalling (IIS) is a critical regulator of an organism’s most important biological decisions from growth, development, and metabolism to reproduction andExpand
Transcriptome analysis of adult Caenorhabditis elegans cells reveals tissue-specific gene and isoform expression
The biology and behavior of adults differ substantially from those of developing animals, and cell-specific information is critical for deciphering the biology of multicellular animals. Thus, adultExpand
A transcriptional switch underlies commitment to sexual development in human malaria parasites
The life cycles of many parasites involve transitions between disparate host species, requiring these parasites to go through multiple developmental stages adapted to each of these specializedExpand
Cell-Specific Transcriptional Profiling of Ciliated Sensory Neurons Reveals Regulators of Behavior and Extracellular Vesicle Biogenesis
Cilia and extracellular vesicles (EVs) are signaling organelles [1]. Cilia act as cellular sensory antennae, with defects resulting in human ciliopathies. Cilia both release and bind to EVs [1]. EVsExpand
Thousands of RNA-cached copies of whole chromosomes are present in the ciliate Oxytricha during development.
The ciliate Oxytricha trifallax maintains two genomes: a germline genome that is active only during sexual conjugation and a transcriptionally active, somatic genome that derives from the germlineExpand
Improvement of PCR-free NGS Library Preparation to Obtain Uniform Read Coverage of Genome with Extremely High AT Content.
PCR amplification is commonly used in generating libraries for Next-Generation Sequencing (NGS) to efficiently enrich and amplify sequenceable DNA fragments. However, it introduces bias in theExpand
Transcriptome Analysis of Adult C. elegans Cells Reveals Tissue-specific Gene and Isoform Expression
The biology and behavior of adults differ substantially from those of developing animals, and cell-specific information is critical for deciphering the biology of multicellular animals. Thus, adultExpand
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