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  • Gang Luo, Mark Cunningham, +18 authors Liang-Shang Gan
  • Chemistry, Medicine
  • Drug metabolism and disposition: the biological…
  • 2002 (First Published: 1 July 2002)
  • Induction of cytochrome P450 3A4 (CYP3A4) is determined typically by employing primary culture of human hepatocytes and measuring CYP3A4 mRNA, protein and microsomal activity. Recently a pregnane XContinue Reading
  • Ajay Madan, Richard A. Graham, +16 authors Andrew Parkinson
  • Chemistry, Medicine
  • Drug metabolism and disposition: the biological…
  • 2003 (First Published: 1 April 2003)
  • Cultured human hepatocytes are a valuable in vitro system for evaluating new molecular entities as inducers of cytochrome P450 (P450) enzymes. The present study summarizes data obtained from 62Continue Reading