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AIMS This study applies pulsed wave Doppler tissue imaging and colour Doppler tissue imaging to study changes in atrial function with ageing. We tested the following hypotheses: (1) pulsed wave Doppler tissue imaging can detect global changes of left atrial function associated with ageing similar to standard echocardiographic methods, (2) colour Doppler(More)
To ascertain the effects of chronic renal failure on the pharmacokinetics of 1R-cis 1'R-cis atracurium besylate (a stereoisomer, designated 51W89), we gave a bolus dose of 0.1 mg kg-1 (2 x ED95) to 17 patients with end-stage renal failure and to 15 patients with normal renal function undergoing elective surgery. All patients received thiopentone, fentanyl(More)
INTRODUCTION Goal-directed therapy (GDT) has been shown in numerous studies to decrease perioperative morbidity and mortality. The mechanism of benefit of GDT, however, has not been clearly elucidated. Targeted resuscitation of the vascular endothelium with GDT might alter the postoperative inflammatory response and be responsible for the decreased(More)
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