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Despite progress in defining genetic risk for psychiatric disorders, their molecular mechanisms remain elusive. Addressing this, the PsychENCODE Consortium has generated a comprehensive online… (More)
Synthetic biology and protein origami both require protein building blocks that behave in a reliable, predictable fashion. In particular, we require protein interaction modules with known specificity… (More)
How innate T cells (ITC), including invariant natural killer T (iNKT) cells, mucosal-associated invariant T (MAIT) cells, and γδ T cells, maintain a poised effector state has been unclear. Here we… (More)
'McCutcheon on Inheritance Tax' is an acknowledged authority on inheritance tax, covering both the theoretical and practical aspects of the tax.
The related Wilcoxon rank sum test and area under the receiver operator curve are ubiquitous in high dimensional biological data analysis. Current implementations do not scale readily to the… (More)
The advent of computational methods has revolutionized the biological fields. We are now able to more closely probe the inner workings of the cell and exercise more fine control in manipulating… (More)
Single-cell methods have revolutionized the study of T cell biology by enabling the identification and characterization of individual cells. This has led to a deeper understanding of T cell… (More)