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A layer-by-layer route to prepare nanoporous Au film materials on transparent ITO substrates is reported by alternatively assembling Au and Ag nanoparticles through 1,5-pentanedithiol as a cross-linker, followed by that Ag nanoparticles are dissolved at room temperature in HAuCl4 solution. Electron transfer of cytochrome c (cyt. c) - an excellent model for(More)
Sensitive and selective monitoring of sialic acid (SA) in cerebral nervous system is of great importance for studying the role that SA plays in the pathological process of Alzheimer's disease (AD). In this work, we first reported an electrochemical biosensor based on a novel stimuli-responsive copolymer for selective and sensitive detection of SA in mouse(More)
A carbon dot (C-Dot)-based two-photon fluorescent probe has been developed for the monitoring of pH changes across a broad range with high sensitivity and selectivity. The inorganic-organic probe also shows good biocompatibility and cell permeability, and thus can be successfully applied in bioimaging and biosensing of physiological pH in living cells, as(More)
A sensitive biosensor: A strategy for the intracellular imaging of Cu(2+) ions has been developed by integrating a recognition molecule, N-(2-aminoethyl)-N,N,N'tris(pyridin-2-ylmethyl)ethane-1,2-diamine (AE-TPEA), into a hybrid system composed of carbon and CdSe/ZnS quantum dots.
In this article, a ratiometric fluorescent biosensor for O2(•-) was developed, by employing carbon dots (C-Dots) as the reference fluorophore and hydroethidine (HE), a specific organic molecule toward O2(•-), playing the role as both specific recognition element and response signal. The hybrid fluorescent probe CD-HE only emitted at 525 nm is ascribed to(More)
Nanoparticles are promising scaffolds for applications such as imaging, chemical sensors and biosensors, diagnostics, drug delivery, catalysis, energy, photonics, medicine, and more. Surface functionalization of nanoparticles introduces an additional dimension in controlling nanoparticle interfacial properties and provides an effective bridge to connect(More)
An efficient protocol for selective and sensitive detection of generated hydroxyl radicals was first developed in the photocatalytic system through an electrochemical impedance method and further successfully applied to monitor hydroxyl radicals in the LPS-mediated cellular ROS/RNS burst process.
Nitrilotriacetic acid (NTA)/histidine-tag (HT) technology has been first employed to facilitate the electron transfer of superoxide dismutase (SOD), and further been developed for in vivo monitoring of superoxide anion (O2(-)) in a rat brain during cerebral ischemia/reperfusion processes. Direct electron transfer of SOD is greatly enhanced at NTA-modified(More)
To develop in vivo monitoring strategies of neurotransmitters involved in brain chemistry is a challenging work for progress in understanding the roles that biomolecules play in pathology and physiology. Here we report a new type of gold nanoparticle-sheathed glass capillary nanoelectrode (Au/GCNE) for sensing cerebral dopamine. First, a size-controlled(More)