Anusha Sriraman

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The Internet has grown tremendously in terms of the number of users who rely on it and the number of organizations that are connected to it. Characterizing how this growth affects its structure and topology is vitally important to determine the fundamental characteristics and limitations that must be handled, such as address space exhaustion ; understanding(More)
Pharmacological inhibition of the cell cycle regulatory kinase Wee1 represents a promising strategy to eliminate cancer cells. Wee1 inhibitors cooperate with chemotherapeutics, e. g. nucleoside analogues, pushing malignant cells from S phase towards premature mitosis and death. However, considerable toxicities are observed in preclinical and clinical(More)
Targeting the Mdm2 oncoprotein by drugs has the potential of re-establishing p53 function and tumor suppression. However, Mdm2-antagonizing drug candidates, e. g. Nutlin-3a, often fail to abolish cancer cell growth sustainably. To overcome these limitations, we inhibited Mdm2 and simultaneously a second negative regulator of p53, the phosphatase Wip1/PPM1D.(More)
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