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- Publications
- Influence
Overexpression of X-linked genes in T cells from women with lupus.
- Anura Hewagama, G. Gorelik, +6 authors B. Richardson
- Biology, Medicine
- Journal of autoimmunity
- 1 March 2013
Women develop lupus more frequently than men and the reason remains incompletely understood. Evidence that men with Klinefelter's Syndrome (XXY) develop lupus at approximately the same rate as women… Expand
The genetics and epigenetics of autoimmune diseases.
- Anura Hewagama, B. Richardson
- Medicine
- Journal of autoimmunity
- 1 August 2009
Self tolerance loss is fundamental to autoimmunity. While understanding of immune regulation is expanding rapidly, the mechanisms causing loss of tolerance in most autoimmune diseases remain elusive.… Expand
Stronger inflammatory/cytotoxic T cell response in women identified by microarray analysis
- Anura Hewagama, Dipak R. Patel, S. Yarlagadda, F. Strickland, B. Richardson
- Biology, Medicine
- Genes and Immunity
- 12 March 2009
Women develop chronic inflammatory autoimmune diseases more often than men. The mechanisms causing the increased susceptibility are incompletely understood. Chronic immune stimulation characterizes… Expand
Environmental exposure, estrogen and two X chromosomes are required for disease development in an epigenetic model of lupus.
- F. Strickland, Anura Hewagama, +8 authors B. Richardson
- Biology, Medicine
- Journal of autoimmunity
- 1 May 2012
Systemic lupus erythematosus (SLE) is an autoimmune disease primarily afflicting women. The reason for the gender bias is unclear, but genetic susceptibility, estrogen and environmental agents appear… Expand
Diet influences expression of autoimmune-associated genes and disease severity by epigenetic mechanisms in a transgenic mouse model of lupus.
- F. Strickland, Anura Hewagama, +7 authors B. Richardson
- Biology, Medicine
- Arthritis and rheumatism
- 1 July 2013
OBJECTIVE
Lupus flares occur when genetically predisposed individuals encounter appropriate environmental agents. Current evidence indicates that the environment contributes by inhibiting T cell DNA… Expand
Stimulatory and Inhibitory Killer Ig-Like Receptor Molecules Are Expressed and Functional on Lupus T Cells1
- Dhiman Basu, Y. Liu, +7 authors B. Richardson
- Biology, Medicine
- The Journal of Immunology
- 1 September 2009
T cells from lupus patients have hypomethylated DNA and overexpress genes normally suppressed by DNA methylation that contribute to disease pathogenesis. We found that stimulatory and inhibitory… Expand
Role of X-Chromosome encoded miRNAs in Autoimmunity: Suppressing the suppressor and Female Predisposition
- Anura Hewagama
- Medicine
- 30 April 2013
Role of skewed X inactivation may in part explain high prevalence of autoimmune diseases in women. Human X chromosome encodes approximately 7% of the total microRNAs identified. Recent studies have… Expand
Functional on Lupus T Cells Receptor Molecules Are Expressed and Stimulatory and Inhibitory Killer Ig-Like Richardson
- Dhiman Basu, Y. Liu, +7 authors B. Richardson
- 2009
- 3
- PDF
Stronger inflammatory/cytotoxic T cell response in women identified by microarray analysis
- Anura Hewagama, Dipak R. Patel, S. Yarlagadda, F. Strickland, B. Richardson
- Medicine
- 20 December 2008
Women develop chronic inflammatory autoimmune diseases like lupus more often than men. The mechanisms causing the increased susceptibility are incompletely understood, although estrogen is believed… Expand
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