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Overexpression of X-linked genes in T cells from women with lupus.
Women develop lupus more frequently than men and the reason remains incompletely understood. Evidence that men with Klinefelter's Syndrome (XXY) develop lupus at approximately the same rate as womenExpand
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The genetics and epigenetics of autoimmune diseases.
Self tolerance loss is fundamental to autoimmunity. While understanding of immune regulation is expanding rapidly, the mechanisms causing loss of tolerance in most autoimmune diseases remain elusive.Expand
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Stronger inflammatory/cytotoxic T cell response in women identified by microarray analysis
Women develop chronic inflammatory autoimmune diseases more often than men. The mechanisms causing the increased susceptibility are incompletely understood. Chronic immune stimulation characterizesExpand
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Environmental exposure, estrogen and two X chromosomes are required for disease development in an epigenetic model of lupus.
Systemic lupus erythematosus (SLE) is an autoimmune disease primarily afflicting women. The reason for the gender bias is unclear, but genetic susceptibility, estrogen and environmental agents appearExpand
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Diet influences expression of autoimmune-associated genes and disease severity by epigenetic mechanisms in a transgenic mouse model of lupus.
OBJECTIVE Lupus flares occur when genetically predisposed individuals encounter appropriate environmental agents. Current evidence indicates that the environment contributes by inhibiting T cell DNAExpand
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Stimulatory and Inhibitory Killer Ig-Like Receptor Molecules Are Expressed and Functional on Lupus T Cells1
T cells from lupus patients have hypomethylated DNA and overexpress genes normally suppressed by DNA methylation that contribute to disease pathogenesis. We found that stimulatory and inhibitoryExpand
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Role of X-Chromosome encoded miRNAs in Autoimmunity: Suppressing the suppressor and Female Predisposition
Role of skewed X inactivation may in part explain high prevalence of autoimmune diseases in women. Human X chromosome encodes approximately 7% of the total microRNAs identified. Recent studies haveExpand
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Stronger inflammatory/cytotoxic T cell response in women identified by microarray analysis
Women develop chronic inflammatory autoimmune diseases like lupus more often than men. The mechanisms causing the increased susceptibility are incompletely understood, although estrogen is believedExpand
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