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The genetics and epigenetics of autoimmune diseases.

• Anura Hewagama, Bruce Dingee Richardson
• Journal of autoimmunity
• 2009

Self tolerance loss is fundamental to autoimmunity. While understanding of immune regulation is expanding rapidly, the mechanisms causing loss of tolerance in most autoimmune diseases remain elusive.… (More)

Stimulatory and inhibitory killer Ig-like receptor molecules are expressed and functional on lupus T cells.

• Dhiman Basu, Ying Liu, +7 authors Bruce C. Richardson
• Journal of immunology
• 2009

T cells from lupus patients have hypomethylated DNA and overexpress genes normally suppressed by DNA methylation that contribute to disease pathogenesis. We found that stimulatory and inhibitory… (More)

Overexpression of X-linked genes in T cells from women with lupus.

• Anura Hewagama, Gabriela Gorelik, +6 authors Bruce C. Richardson
• Journal of autoimmunity
• 2013

Women develop lupus more frequently than men and the reason remains incompletely understood. Evidence that men with Klinefelter's Syndrome (XXY) develop lupus at approximately the same rate as women… (More)

Stronger inflammatory/cytotoxic T cell response in women identified by microarray analysis

• Anura Hewagama, Dipak Ramjibhai Patel, Sushma Yarlagadda, Faith M. Strickland, Bruce C. Richardson
• Genes and Immunity
• 2009

Women develop chronic inflammatory autoimmune diseases more often than men. The mechanisms causing the increased susceptibility are incompletely understood. Chronic immune stimulation characterizes… (More)

Environmental exposure, estrogen and two X chromosomes are required for disease development in an epigenetic model of lupus.

• Faith M. Strickland, Anura Hewagama, +8 authors Bruce C. Richardson
• Journal of autoimmunity
• 2012

Systemic lupus erythematosus (SLE) is an autoimmune disease primarily afflicting women. The reason for the gender bias is unclear, but genetic susceptibility, estrogen and environmental agents appear… (More)

Diet influences expression of autoimmune-associated genes and disease severity by epigenetic mechanisms in a transgenic mouse model of lupus.

• Faith M. Strickland, Anura Hewagama, +7 authors Bruce C. Richardson
• Arthritis and rheumatism
• 2013

OBJECTIVE Lupus flares occur when genetically predisposed individuals encounter appropriate environmental agents. Current evidence indicates that the environment contributes by inhibiting T cell DNA… (More)

Role of X Chromosome Encoded miRNAs in Autoimmunity

• Anura Hewagama
• 2013

Autoimmune disorders develop when the body’s immune system mistakenly attacks and destroys its own healthy tissues. Autoimmunity is believed to develop when genetically predisposed individuals… (More)

Role of X-Chromosome encoded miRNAs in Autoimmunity: Suppressing the suppressor and Female Predisposition

• Anura Hewagama
• 2013

Role of skewed X inactivation may in part explain high prevalence of autoimmune diseases in women. Human X chromosome encodes approximately 7% of the total microRNAs identified. Recent studies have… (More)

Computational Prediction of c-MYC Binding and Action by Integration of Multiple Data Sources.

• Yili Chen, Thomas W. Blackwell, +4 authors David J. States
• 2006

c- MYC is an important proto-oncogene. Its actions are mediated by sequence specific binding of the c- MYC protein to genomic DNA. While many c- MYC recognition sites can be identified in c- MYC… (More)

Functional on Lupus T Cells Receptor Molecules Are Expressed and Stimulatory and Inhibitory Killer Ig-Like Richardson

• Dhiman Basu, Ying Liu, +7 authors Bruce C. Richardson
• 2009

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