Anupam Sinha

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The binding and contribution of transcription factors (TF) to cell specific gene expression is often deduced from open-chromatin measurements to avoid costly TF ChIP-seq assays. Thus, it is important to develop computational methods for accurate TF binding prediction in open-chromatin regions (OCRs). Here, we report a novel segmentation-based method, TEPIC,(More)
BACKGROUND & OBJECTIVES Mucopolysaccharidosis type VI (MPS VI) is a rare, autosomal recessive lysosomal storage disorder caused by deficient enzymatic activity of N-acetyl galactosamine-4-sulphatase resulting from mutations in the arylsulphatase B (ARSB) gene. The ARSB gene is located on chromosome 5q11-q13 and is composed of eight exons. More than hundred(More)
1 Introduction The design of fault-tolerant systems is a challenging problem. It requires close attention to many issues, e.g., the fault-model, the connectivity of the system topology, the concurrent programming paradigm used (say, for instance, synchronous message passing), the message transfer delays of the communication network, the support for(More)
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