Anuja A George

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Prevalent Glucocorticoid and Androgen Activity in US Water Sources

Diana A. Stavreva, Anuja A George, +7 authors Gordon L. Hager
Scientific reports
2012

Contamination of the environment with endocrine disrupting chemicals (EDCs) is a major health concern. The presence of estrogenic compounds in water and their deleterious effect are well documented.… (More)

Dynamic access of the glucocorticoid receptor to response elements in chromatin.

Anuja A George, R. Louis Schiltz, Gordon L. Hager
The international journal of biochemistry & cell…
2009

Transcriptional activation as a rate-limiting step of gene expression is often triggered by an environmental stimulus that is transmitted through a signaling cascade to specific transcription… (More)

Kinetochore Components Required for Centromeric Chromatin Assembly Are Impacted by Msc1 in Schizosaccharomyces pombe.

Chenchao Gao, Lauren Langbein, Fariha Kamal, Anuja A George, Nancy C Walworth
Genetics
2017

Eukaryotic chromosome segregation requires a protein complex known as the kinetochore that mediates attachment between mitotic spindle microtubules and centromere-specific nucleosomes composed of the… (More)

Identification of compounds by high-content screening that induce cytoplasmic to nuclear localization of a fluorescent estrogen receptor α chimera and exhibit agonist or antagonist activity in vitro.

Angie B. Dull, Anuja A George, +5 authors J. McMahon
Journal of biomolecular screening
2014

We have completed a robust high-content imaging screen for novel estrogen receptor α (ERα) agonists and antagonists by quantitation of cytoplasmic to nuclear translocation of an estrogen receptor… (More)

Escape from Mitotic Arrest: An Unexpected Connection Between Microtubule Dynamics and Epigenetic Regulation of Centromeric Chromatin in Schizosaccharomyces pombe.

Accurate chromosome segregation is necessary to ensure genomic integrity. Segregation depends on the proper functioning of the centromere, kinetochore, and mitotic spindle microtubules and is… (More)

Transcription regulation from a TATA and INR-less promoter: spatial segregation of promoter function.

Anuja A George, Manish Sharma, Badri Nath Singh, Naresh C. Sahoo, Kanury V S Rao
The EMBO journal
2006

The mode of regulation of class II genes that lack the known core promoter elements is presently unclear. Here, we studied one such example, the murine CD80 gene. An unusual mechanism was revealed… (More)

Microtubule dynamics decoded by the epigenetic state of centromeric chromatin

Anuja A George, Nancy C Walworth
Current Genetics
2016

Cell division with accurate chromosome segregation is fundamental to cell survival of all organisms. The precise molecular mechanisms that ensure accurate chromosome segregation are still being… (More)

Regulation of transcript elongation through cooperative and ordered recruitment of cofactors.

Manish Sharma, Anuja A George, Badri Nath Singh, Naresh C. Sahoo, Kanury V. S. Rao
The Journal of biological chemistry
2007

We studied the regulation of murine CD80, a gene whose basal transcriptional status was characterized by the presence of a stalled RNA polymerase II complex on the promoter-proximal region.… (More)

Novel cell-based assay for detection of thyroid receptor beta-interacting environmental contaminants.

Diana A. Stavreva, Lyuba Varticovski, +6 authors Gordon L. Hager
Toxicology
2016

Even though the presence of endocrine disrupting chemicals (EDCs) with thyroid hormone (TH)-like activities in the environment is a major health concern, the methods for their efficient detection and… (More)

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