Learn More
This paper presents a novel variable step-size LMS (VSLMS) algorithm for tracking signals from the Gaussian 1/f<sup>beta</sup> family of fractal signals that are inherently nonstationary. The proposed algorithm differs from the existing VSLMS algorithms in the following ways: 1) it deals with a specific class of nonstationary signals, 2) it utilizes a(More)
This paper proposes a new method of estimating both biorthogonal compactly supported as well as semi-orthogonal infinitely/compactly supported wavelet from a given signal. The method is based on maximizing projection of the given signal onto successive scaling subspace. This results in minimization of energy of signal in the wavelet subspace. The idea used(More)
Lenvatinib is an orally available multi-targeted tyrosine kinase inhibitor with anti-angiogenic and antitumor activity. To get more insight into the disposition of lenvatinib, a mass balance study was performed in patients with advanced solid tumors. A single oral 24 mg (100 μCi) dose of (14)C-lenvatinib was administered to six patients, followed by(More)
Lenvatinib significantly prolonged progression-free survival (PFS) versus placebo in patients with radioiodine-refractory differentiated thyroid cancer (RR-DTC) in the phase 3 Study of (E7080) Lenvatinib in Differentiated Cancer of the Thyroid (SELECT) trial. This subanalysis evaluated the efficacy and safety of lenvatinib in Japanese patients who(More)
AIMS Lenvatinib was recently approved for the treatment of radioiodine-refractory differentiated thyroid cancer (RR-DTC). Here, we characterized the pharmacokinetic (PK) profile of lenvatinib and identified intrinsic and extrinsic factors that explain interindividual PK variability in humans. METHODS This population PK analysis used pooled data from 15(More)
AIM To evaluate dosing and intervention strategies for the phase II programme of a VEGF receptor inhibitor using PK-PD modelling and simulation, with the aim of maximizing (i) the number of patients on treatment and (ii) the average dose level during treatment. METHODS A previously developed PK-PD model for lenvatinib (E7080) was updated and parameters(More)
AIMS Eribulin mesilate is an inhibitor of microtubule dynamics that is approved for the treatment of late-stage metastatic breast cancer. Neutropenia is one of the major dose-limiting adverse effects of eribulin. The objective of this analysis was to develop a population pharmacokinetic-pharmacodynamic model for eribulin-associated neutropenia. METHODS A(More)
OBJECTIVE To determine the effect of artesunate (AT) on the disposition kinetics of sulfadoxine/pyrimethamine (SP) in humans. METHODS In a randomized cross-over study, 16 healthy volunteers were given a dose of three SP tablets containing 500 mg of sulfadoxine (SDX) and 25 mg of pyrimethamine (PYR) (=SP group), while the second arm received three SP(More)
This paper presents novel methods for baseline wander removal and powerline interference removal from electrocardiogram (ECG) signals. Baseline wander and clean ECG have been modeled as 1st and 2nd-order fractional Brownian motion (fBm) processes, respectively. This fractal modeling is utilized to propose projection operator based approach for baseline(More)
This paper presents a new approach for the estimation of wavelets that is matched to a given signal in the statistical sense. Based on this approach, a number of new methods to estimate statistically matched wavelets are proposed. The paper first proposes a new method for the estimation of statistically matched two-band compactly supported biorthogonal(More)