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Oxysterol binding proteins (OSBPs) comprise a large conserved family of proteins in eukaryotes. Their ubiquity notwithstanding, the functional activities of these proteins remain unknown. Kes1p, one of seven members of the yeast OSBP family, negatively regulates Golgi complex secretory functions that are dependent on the action of the major yeast(More)
Monitoring protein-protein interactions in living cells is key to unraveling their roles in numerous cellular processes and various diseases. Previously described split-GFP based sensors suffer from poor folding and/or self-assembly background fluorescence. Here, we have engineered a micro-tagging system to monitor protein-protein interactions in vivo and(More)
The problem of finding the shortest path between two nodes is a well known problem in network analysis. Optimal routing has been widely studied for interconnection networks this paper considers the problem of finding the shortest path. A Genetic algorithm based strategy is proposed and the algorithm has been developed to find the shortest (Optimal) Path(More)
An understanding of common human diversity in innate immune pathways should be beneficial in understanding autoimmune diseases, susceptibility to infection, and choices of anti-inflammatory treatment. Such understanding could also result in definition of currently unknown components of human inflammation pathways. A cellular genome-wide association studies(More)
Mutations in genes encoding autophagy proteins have been associated with human autoimmune diseases, suggesting that diversity in autophagy responses could be associated with disease susceptibility or severity. A cellular genome-wide association study (GWAS) screen was performed to explore normal human diversity in responses to rapamycin, a microbial product(More)
Automatic Generation Control is necessary for reliable & continuous operation of power system which is obtained by using different controllers. For efficient operation of the system, optimization of the different controlling parameters is necessary which can be obtained by using optimization techniques. Some of these techniques like genetic algorithm, BF,(More)
Recent advancements in network technology allow integration of different services on the same networking infrastructure. Thus, voice, data and video or multimedia traffic share the same transmission, switching and storage resources over a single network. This integration offers the user a single access facility to all communication services through a(More)
This study was carried out to investigate the antioxidant and free radical scavenging activity of methanolic extract of Madhuca indica bark in varios systems. DPPH radical, superoxide anion radical, nitric oxide radical, hydroxyl radical, lipid peroxidation, and total phenolic content assays were carried out to evaluate the antioxidant potential of the(More)
Extended Abstract Toll-like receptors (TLRs) offer the first line of host defense by recognizing the danger signals of pathogen and by inducing intracellular signaling that culminate in pathogen specific innate immune responses. We have been studying the early events that occur upon engagement of TLRs in cells. These events include protein phosphorylation(More)