Antti Nissinen

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BACKGROUND Pneumococcus is a leading cause of childhood pneumonia worldwide. Pneumococcal conjugate vaccines (PCV) have demonstrated efficacy against childhood invasive pneumococcal disease (IPD) and pneumonia in the United States and Africa. No information is available from Asia on the impact of PCV on childhood pneumonia. METHODS We conducted a(More)
Electrical impedance tomography is a highly unstable problem with respect to measurement and modeling errors. This instability is especially severe when absolute imaging is considered. With clinical measurements, accurate knowledge about the body shape is usually not available, and therefore an approximate model domain has to be used in the computational(More)
OBJECTIVES The objective of this multicentre study was to define the accuracy and reproducibility of the NCCLS disc diffusion method for Haemophilus influenzae against ampicillin and co-amoxiclav in Finnish clinical microbiology laboratories. Special attention was paid to the ability of the laboratories to detect beta-lactamase-negative ampicillin-resistant(More)
OBJECTIVE Tetracycline derivatives affect many cellular functions relevant to chronic cardiovascular pathologies, including cell proliferation, migration and matrix remodelling. Accordingly, we sought to determine whether they may modulate the pathologic characteristics known to be significantly involved in human aortic valve stenosis, such as gelatinase(More)
BACKGROUND Urinary tract infection (UTI) is the most common diagnosis made in prescribing antimicrobials in long-term care facilities (LTCF). The diagnostic criteria for UTI vary among institutions and prescribers. Our aim was to reduce the inappropriate use of antimicrobials in LTCFs. METHODS A team comprising infectious disease consultant, infection(More)
Electrical impedance tomography (EIT) is a highly unstable problem with respect to measurement and modeling errors. This instability is especially severe when absolute imaging is considered. With clinical measurements, accurate knowledge about the body shape is usually not available, and therefore an approximate model domain has to be used in the(More)
Electrical impedance tomography (EIT) is a highly unstable problem with respect to measurement and modeling errors. With clinical measurements, knowledge about the body shape is usually uncertain. Since the use of an incorrect model domain in the measurement model is bound to lead to severe estimation errors, one possibility is to estimate both the(More)
In electrical impedance tomography (EIT), electrodes are attached on the boundary of the object and currents are injected into the object. The voltages are measured using the same electrodes and the conductivity of the object is reconstructed based on the measured voltages. The reconstruction problem is a non-linear ill-posed inverse problem, i.e. the(More)
Knowledge of the quality and conformity of antimicrobial resistance data is important for comparing resistance rates regionally and over time. In this study, we have evaluated these features of the Finnish national susceptibility surveillance data for two respiratory tract pathogens, Streptococcus pneumoniae and Haemophilus influenzae. For this purpose(More)