Antti L Pakkanen

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The interactions of three neuroleptic drugs, clozapine (CLZ), chlorpromazine (CPZ), and haloperidol (HPD) with phospholipids were compared using DSC and Langmuir balance. Main emphasis was on the drug-induced effects on the lateral organization of lipid mixtures of the saturated zwitterionic 1,2-dipalmitoyl-sn-glycero-3-phosphatidylcholine (DPPC) and the(More)
The effects of three so-called kosmotropic solutes, namely, betaine, sucrose, and choline chloride on 1-palmitoyl-2-oleoyl-sn-glycero-3-phosphocholine large unilamellar vesicles, were studied by measuring the generalized polarization (GP) for the fluorescence emission of the membrane partitioning probe Laurdan. The latter has been shown to be sensitive to(More)
Developments in gene therapy have led to a need for new and more efficient transfection vectors. So far, the use of viruses has received major attention. During the recent years, however, cationic liposomes have emerged as a potential rival for viruses and have several advantages, e.g. nonimmunogenity, low toxicity and a capability to carry larger amounts(More)
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