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The widening gap between CPU and memory speed has made caches an integral feature of modern high- performance processors. The high degree of configurability of cache memory can require extensive design space exploration and is generally performed using execution-driven or trace-driven simulation. Execution-driven simulators can be highly accurate but(More)
Recent data demonstrated that activation of the muscarinic M1 receptor by a subtype-selective positive allosteric modulator (PAM) contributes to the gastrointestinal (GI) and cardiovascular (CV) cholinergic adverse events (AEs) previously attributed to M2 and M3 activation. These studies were completed using PAMs that also exhibited allosteric agonist(More)
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