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BACKGROUND This study introduces a laboratory model of compulsive behavior based on persistence in the context of rewarded spatial alternation. METHODS Rats were screened for spontaneous persistence during T-maze reinforced alternation. Experiment 1: One high and one low spontaneous persistence group (n = 8) received 20 injections of fluoxetine, a matched(More)
Electroencephalographic oscillations, with different spectral contents, recorded in various brain sites are assumed to play an important role in the information processes underlying cognition as well as the abnormal brain functioning observed in nosological entities that affect neuronal connectivity such as schizophrenia. In the present study we(More)
In the present in vivo experimental study the complexity alterations of the hippocampal electroencephalographic (EEG) activity were investigated prior and during the maintenance phase of long-term potentiation (LTP), using analytical methods based on the recent concepts of deterministic chaos. LTP was induced in the hippocampal dentate hilus after(More)
Thought blocks (TBs) are characterized by regular interruptions in the stream of thought. Outward signs are abrupt and repeated interruptions in the flow of conversation or actions while subjective experience is that of a total and uncontrollable emptying of the mind. In the very limited bibliography regarding TB, the phenomenon is thought to be(More)
CONTEXT No rating scales of the neuropsychiatric symptoms of patients with dementia and Alzheimer's disease (AD) have previously been developed or translated. OBJECTIVES To develop a Hellenic translation of the Neuropsychiatric Inventory (NPI), to evaluate it's reliability and validity, and to compare NPI results in Greek patients referred to a(More)
It was recently shown that induction of long-term potentiation (LTP) in the visual cortex of adult rats does not require suppression of inhibition or N-methyl-D-aspartate (NMDA) receptor activation. In the present study we examined the role of dihydropyridine-sensitive Ca2+ channels in the induction of this form of LTP. In visual cortical slices from 60 to(More)
Auditory verbal hallucinations (AVHs), the perception of voices in the absence of auditory stimuli, are common and distressing symptoms reported by 50%-80% of patients with schizophrenia. However, the results in a number of imaging and electrophysiological studies on the origins of AVH are not consistent, and the underlying pathophysiology remains unclear.(More)
Piracetam, when applied microiontophoretically and/or by hydropneumatic pump on the somatosensory cortex and hippocampus of the rat, affected neuronal activity by depressing or facilitating the spontaneous firing rate, depending on the area studied. Its effect were either additive or counteracting the actions of glutamate, gamma-aminobutyric acid and(More)
Introduction. Chronic pain of the oral cavity is a long-term condition and like all other types of chronic pain is associated with numerous comorbidities such as depression or anxiety. Case Presentation. This is a case of a 93-year-old patient suffering from chronic oral cavity pain who repeatedly stabbed his palate due to ongoing local pain, over the last(More)
The 22q11.2 deletion syndrome (di George syndrome) is one of the most prevalent genetic disorders. The clinical features of the syndrome are distinct facial appearance, velopharyngeal insufficiency, conotruncal heart disease, parathyroid and immune dysfunction; however, little is known about possible neurodegenerative diseases. We describe the case of an(More)