Antonio del Águila

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Lactoferrin (Lf) is an iron-binding protein of external secretions and neutrophil secondary granules with antimicrobial and immunomodulatory activities. To further define these properties of Lf, we have investigated the response to Staphylococcus aureus infection in transgenic mice carrying a functional human Lf gene. The transgenic mice cleared bacteria(More)
There is increasing concern over the efficacy of existing vaccines for diphtheria and there is interest in the development of a mucosally active formulation which might improve local protection. Lipophilic immune stimulating complexes (ISCOMS) containing Quil A are active by both parenteral and mucosal routes and here we have established methods for(More)
Some evidence on the possible use of sodium dodecyl sulfate-polyacrylamide gel electrophoresis (SDS-PAGE) to elicit antibodies against smooth- or rough-type bacterial lipopolysaccharides (LPS) is shown. Gel-separated LPS were negatively stained with zinc-imidazole to precisely localize the bands of interest under fully reversible conditions. Then the bands(More)
To further characterize the inocuousness and biological activity of a local preparation of human colostral lactoferrin, a study of its cytotoxicity and antiviral activity was undertaken. Using the HSV-1/Vero cell model, this colostral lactoferrin preparation was shown to exert a significant antiviral activity against HSV-1 at parameters (CC5054.3 μM, ED50(More)
Hyperopia is a common refractive error, particularly in young children. Although its prevalence has not been studied to the same extent as myopia, knowledge of its rates among the world population, its early detection and treatment is a matter of vital importance, since moderate or high degrees of this refractive error may lead to other visual impairment(More)
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