Antonio T. Pedrosa

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Bacterial type III secretion system (T3SS) chaperones pilot substrates to the export apparatus in a secretion-competent state, and are consequently central to the translocation of effectors into target cells. Chlamydia trachomatis is a genetically intractable obligate intracellular pathogen that utilizes T3SS effectors to trigger its entry into mammalian(More)
PURPOSE The purpose of this retrospective investigation was to evaluate the influence on the adjacent cervical bone of moving the implant-abutment microgap inward from the outer edge of an internal-hex implant platform (ie, a platform-switched configuration). MATERIALS AND METHODS A convenience sample of 26 patients received 42 Frialit-2(More)
OBJECTIVE Variables predicting optimal timing for tracheostomy decannulation remain unknown. We aimed to determine whether classifying patients into two groups according to their indications for tracheostomy could identify variables associated with time to decannulation. DESIGN A prospective, observational cohort study was carried out. LOCATION Two(More)
The mammalian protein vinculin is often a target of bacterial pathogens to subvert locally host cell actin dynamics. In Chlamydia infection, vinculin has been implicated in RNA interference screens, but the molecular basis for vinculin requirement has not been characterized. In this report, we show that vinculin was involved in the actin recruitment and(More)
Chlamydiae are obligate intracellular pathogens. They undergo a biphasic developmental cycle differentiating between the infectious but metabolically quiescent elementary body and the vegetative, but non-infectious reticulate body. Chlamydia spends a significant portion of its development in the non-infectious stage, demanding an effective strategy of(More)
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