Antonio Possolo

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2,3,7,8-Tetrachlorodibenzo-p-dioxin (TCDD) and related chemicals induce cytochrome P450 1A (CYP1A) gene expression and, at sufficient exposures, cause toxicity. Human health risks from such exposures are typically estimated from animal studies. We tested whether animal models predict human sensitivity by characterizing CYP1A gene expression in cultures of(More)
Fugitive losses from natural gas distribution systems are a significant source of anthropogenic methane. Here, we report on a national sampling program to measure methane emissions from 13 urban distribution systems across the U.S. Emission factors were derived from direct measurements at 230 underground pipeline leaks and 229 metering and regulating(More)
Single particle inductively coupled plasma-mass spectrometry (spICP-MS) is an emerging technique that enables simultaneous measurement of nanoparticle size and number quantification of metal-containing nanoparticles at realistic environmental exposure concentrations. Such measurements are needed to understand the potential environmental and human health(More)
A large, multi-laboratory microcosm study was performed to select amendments for supporting reductive dechlorination of high levels of trichloroethylene (TCE) found at an industrial site in the United Kingdom (UK) containing dense non-aqueous phase liquid (DNAPL) TCE. The study was designed as a fractional factorial experiment involving 177 bottles(More)
Subsampling techniques developed by Hartigan (for independent observations) and by Carlstein (for mixing processes on the integers) are extended to estimate variances and covariances of statistics of spatial processes. If the process is stationary, and dependence weakens rapidly with increasing distance, then the procedure is consistent in the sense that,(More)
This introduction to the R package alphashape3d is a (slightly) modified version of Lafarge, Pateiro-López, Possolo, and Dunkers (2014), published in the Journal of Statistical Software. This work presents the implementation in R of the α-shape of a finite set of points in the three–dimensional space R. This geometric structure generalizes the convex hull(More)
Energy Harvesting (EH) refers to the process of capturing and storing energy from external sources or ambient environment. Kinetic energy harvested from the human body motion seems to be one of the most convenient and attractive solution for wearable wireless sensors in healthcare applications. Due to their small size, such sensors have a very limited(More)
In 1994, the leadership of the US Biometric Consortium asked a series of questions to the automated human recognition (“biometrics”) community revolving around the issues of repeatability and reproducibility of measurements in performance testing. Although we have made significant progress in our understanding, these issues have not been totally resolved.(More)
PURPOSE Computed Tomography (CT) imaging of the lung, reported in Hounsfield Units (HU), can be parameterized as a quantitative image biomarker for the diagnosis and monitoring of lung density changes due to emphysema, a type of chronic obstructive pulmonary disease (COPD). CT lung density metrics are global measurements based on lung CT number histograms,(More)